15516-43-5

Basic information

• Product Name: (2-methylphenoxy)acetyl chloride
• Synonyms: (2-methylphenoxy)acetyl chloride;acetyl chloride, (2-methylphenoxy)-
• CAS NO: 15516-43-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Mol File: 15516-43-5.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-methylphenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenoxy)acetyl chloride(15516-43-5)
• EPA Substance Registry System: (2-methylphenoxy)acetyl chloride(15516-43-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15516-43-5(Hazardous Substances Data)

Usage

General Description

(2-methylphenoxy)acetyl chloride is a chemical compound consisting of a phenyl ring with a methyl group attached to it, and an acetyl chloride group (CH3COCl) attached to the phenyl ring. It is typically used as a reagent in organic synthesis, particularly in the acylation of organic compounds. (2-methylphenoxy)acetyl chloride is known for its strong acylating properties, and it is often utilized to introduce acetyl groups into various substrates. It is important to handle this compound with care, as acetyl chloride is a highly reactive and corrosive compound that can cause severe burns and irritation to the skin, eyes, and respiratory tract upon exposure.

Upstream product

• 79-37-8 oxalyl dichloride 
• 1878-49-5 o-methylphenoxyacetic acid 
• 2989-17-5 methyl 2-methylphenoxy acetate 
• 13078-21-2 ethyl 2-(2-methoxyphenoxy)acetate 
• 1878-85-9 (2-methoxyphenoxy)acetic acid 
• 90-05-1 2-methoxy-phenol 
• 95-48-7 ortho-cresol 
• 4549-72-8 sodium o-cresolate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 131253-20-8 o-tolyloxy-acetic acid-(2-diethylamino-ethylamide); hydrochloride 
• 2021-06-9 4-o-tolyloxyacetyl-morpholine 
• 57628-26-9 N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-2-o-tolyloxy-acetamide 
• 41648-60-6 10-o-tolyloxyacetyl-10H-phenothiazine 
• 129803-41-4 C₁₈H₃₁NO₅Si 
• 134145-73-6 1-Carbazol-9-yl-2-o-tolyloxy-ethanone 
• 3839-47-2 N-Isobutyl-o-tolyloxyacetamid 
• 3898-29-1 N-tert.Butyl-o-tolyloxyacetamid 
• 2021-09-2 N,N-Diethyl-2-methylphenoxyacetamid 
• 3898-30-4 N-Butyl-o-tolyloxyacetamid 
• 109393-45-5 N-o-tolyloxyacetyl-anthranilic acid methyl ester 
• 58903-19-8 2-methylphenyloxyacetyl thioisocyanate 
• 330950-54-4 C₂₄H₂₂N₂O₃ 
• 7542-40-7 4-(o-Tolyloxy-acetoxy)-cumarin 

Relevant articles and documents

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

Isoflavone amide derivatives, their preparation method and medical use

The invention belongs to the field of medicinal chemistry, and relates to derivatives of isoflavones amides, as well as a preparation method and medical application of derivatives, in particular to the derivatives of the isoflavones amides with the general formula of (I) shown as the specification, the preparation method and the medical application of the derivatives, particularly the application of the derivatives of the isoflavones amides serving as medicaments for preventing or treating hyperlipemia, adiposis or type-II diabetes.

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents

A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented.