82160-11-0Relevant academic research and scientific papers
Chiral lithium amide mediated asymmetric synthesis of 3-aryl-3,4- dihydroisocoumarins
Sharma, Arvind Kumar,Maheshwary, Yogita,Singh, Paramjit,Singh, Kamal Nain
scheme or table, p. 54 - 62 (2010/10/19)
An asymmetric synthesis of 3-aryl-3,4-dihydroisocoumarins using the reaction of laterally lithiated 4,4-dimethyl-2-(o-tolyl)oxazoline with aromatic aldehydes, in the presence of an external chiral ligand, gave products with enantiomeric excess (ee) in the range of 60-70%. ARKAT USA, Inc.
PREPARATION OF PROLINE DERIVED LITHIUM AMIDE BASES AND THEIR USE IN ENANTIOSELECTIVE DEPROTONATION OF MESO EPOXIDES
Hendrie, Shirley K.,Leonard, John
, p. 3289 - 3294 (2007/10/02)
An alternative method of preparation for a range of proline derived chiral lithium amide bases is described. (S)-2-(Pyrrolidinomethyl) pyrrolidine, prepared by the new route, has been used to deprotonate cis and trans tbutyldimethylisiloxy-3,4-epoxycyclopentane enantioselectively, thus generating chiral cis and trans tbutyldimethylsiloxy-2-cyclopenten-4-ols.The products had higher enantiomeric purity than those produced when the base was prepared by a previously reported method.
