82190-91-8Relevant academic research and scientific papers
P-fluorobenzoyl-piperidino alkyl theophylline derivatives
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, (2008/06/13)
New derivatives of theophylline having the formula STR1 wherein R is hydrogen or a hydroxy group, and n is an integer of 0≤n≤3 and/or the pharmaceutically acceptable, acid addition salts thereof, exhibit in addition to other properties, histamine-serotini
New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline
Thiele,Jahn,Geissmann,Zirngibl
, p. 1 - 4 (2007/10/02)
Within the course of the research project for finding new cardiovascular drugs we have synthetized since 1976 piperazine- and piperidine derivatives of theophylline. The screening shows for the substances Sgd 19578 (flufylline) and Sgd 14480 (fluprofylline) a long-lasting blood pressure lowering activity as well as a remarkable serotonin- and histamine antagonism and broncholytic activity. On the basis of these results these compounds were selected for further investigation.
