5878-61-5Relevant academic research and scientific papers
Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation
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, (2008/06/13)
A method of treating skin or hair for promoting pigmentation wherein a xanthine component, in an amount effective to promote pigmentation, is incorporated in liposomes or hydrated lipidic lamellar phases.
Synthesis, toxicological and pharmacological assessment of 7-substituted derivatives of 1,3-dimethylxanthine
Peikov,Zlatkov,Markov,Danchev,Ivanov,Panova
, p. 295 - 299 (2007/10/02)
The synthesis of two 7-substituted theophylline derivatives from the theophylline sodium salt, dichloroalkane and N-methyl-N-cyclohexylamine is reported. The structures of the synthesized compounds were proved by microanalyses and 1H-NMR data. Acute toxicity studies of the compounds were performed on mice and rats. A comparative pharmacological study of the in vivo broncholytic effect of the derivatives and aminophylline showed that the new compounds have different bronchodilatory activity and the compound 7-[2-(N-methyl-N-cyclohexyl)-aminoethyl]-1,3-dimethylxanthine tartrate 3a was more active than 7-[3-(N-methyl-N-cyclohexyl)-aminopropyl]-1,3-dimethylxanthine hydrochloride 3b. It was demonstrated that compound 3b and aminophylline exerted the strongest inhibitory effect on the enzyme activity of phosphodiesterase in lung homogenate. Compound 3a showed a slight inhibitory effect on the enzyme activity in this homogenate. The possible mechanisms of the broncholytic effects of these compounds are discussed.
Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
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, (2008/06/13)
According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.
