82199-98-2 Usage
General Description
1H-Indole,7-acetonitrile is a chemical compound with the molecular formula C10H9N. It is a derivative of indole, which is a heterocyclic aromatic compound. 1H-Indole,7-acetonitrile is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its role as an intermediate in the production of various compounds, including dyes, perfumes, and flavorings. This chemical is also used as a precursor in the synthesis of tryptophan, which is an essential amino acid in the human diet. Additionally, 1H-Indole,7-acetonitrile has been studied for its potential pharmacological properties, including its activity as an antitumor agent and its ability to inhibit the growth of cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 82199-98-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,1,9 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 82199-98:
(7*8)+(6*2)+(5*1)+(4*9)+(3*9)+(2*9)+(1*8)=162
162 % 10 = 2
So 82199-98-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2/c11-6-4-8-2-1-3-9-5-7-12-10(8)9/h1-3,5,7,12H,4H2
82199-98-2Relevant articles and documents
Synthesis of N-protected/free indole-7-carboxaldehyde
Mohanakrishnan, Arasambattu K.,Balamurugan, Ramalingam,Ramesh, Neelamegam,Mathiselvam, Manoharan,Manavalan, Subramaniam
, p. 4343 - 4352 (2008/03/13)
A direct method for the preparation of N-protected/free indole-7-carboxaldehyde is reported from the corresponding N-protected 7-bromomethylindoles using three different conditions. Copyright Taylor & Francis Group, LLC.
PURINE DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 47, (2008/06/13)
The present invention provides kinase inhibitors of Formula I.
An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles
Engler, Thomas A.,Furness, Kelly,Malhotra, Sushant,Diefenbacher, Clive,Clayton, Joshua R.
, p. 2903 - 2905 (2007/10/03)
Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.
