82199-98-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole,7-acetonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1H-Indole,7-acetonitrile is used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Dye Industry:
1H-Indole,7-acetonitrile is used as an intermediate in the production of various dyes, providing color and properties to a range of products.
Used in Perfumery Industry:
1H-Indole,7-acetonitrile is used as a precursor in the synthesis of perfumes, contributing to the creation of unique and complex fragrances.
Used in Flavoring Industry:
1H-Indole,7-acetonitrile is used as a building block in the synthesis of flavorings, enhancing the taste and aroma of various food products.
Used in Nutritional Supplements:
1H-Indole,7-acetonitrile is used as a precursor in the synthesis of tryptophan, an essential amino acid in the human diet, contributing to the development of nutritional supplements and health products.
Used in Cancer Research:
1H-Indole,7-acetonitrile is used as an antitumor agent in cancer research, exhibiting potential activity against cancer cells and providing a basis for the development of new cancer treatments.

InChI:InChI=1/C10H8N2/c11-6-4-8-2-1-3-9-5-7-12-10(8)9/h1-3,5,7,12H,4H2

Upstream product

• 120-72-9 indole 
• 99749-00-5 lithioacetonitrile 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 2942-58-7 diethyl cyanophosphonate 

Relevant academic research and scientific papers

Synthesis of N-protected/free indole-7-carboxaldehyde

A direct method for the preparation of N-protected/free indole-7-carboxaldehyde is reported from the corresponding N-protected 7-bromomethylindoles using three different conditions. Copyright Taylor & Francis Group, LLC.

Methods and compounds for treating proliferative diseases

The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

PURINE DERIVATIVES AS KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula I.

KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula (I)

An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.

Novel, potent and selective cyclin D1/CDK4 inhibitors: Indolo[6,7-a]pyrrolo[3,4-c]carbazoles

The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.

ADDITION OF CARBON NUCLEOPHILES TO ARENE-CHROMIUM COMPLEXES

The electrophilic reactivity of arenes coordinated to the chromium tricarbonyl unit has been developed into several distinct methods for coupling carbon nucleophiles with aromatic rings.Addition of the nucleophile produces stable η-cyclohexadienyl chromium complexes which can be oxidized to induce loss of the endo hydrogen and the metal, overall nucleophilic substitution for hydrogen.Alternatively, the intermediate can be protonated and the resulting cyclohexa-1,3-diene can be detached from the chromium, effecting nucleophilic addition with reduction of one double bond.If a halogen (F, Cl) is present as a ring substituent, and if the nucleophile can migrate about the arene ligand, then loss of halide can occur parallel with classical nucleophilic aromatic substitution for halogen in electron-deficient haloarenes.With substituted arenes, the regioselectivity of addition becomes important and is often very high.Particularly useful are strong resonance donor substituents (RO-, R2N-, F-) where selectivity for meta attack is high.Indole provides an excellent example of selective activation, as the six-membered ring complexes selectively and is then susceptible to nucleophilic substitution, predominantly at the 4 and 7 positions.Substitution for halogen is a somewhat limited process and depends upon the nature of the nucleophile.Very reactive nucleophiles add to unsubstituted positions and are often slow to isomerize to the ipso position from which loss of halide can occur.