82205-00-3

Usage

Uses

Used in Pharmaceutical Industry:
Estradiol-17-stearate is used as a pharmaceutical agent for hormone replacement therapy (HRT) in postmenopausal women. It helps alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness, by providing the body with the necessary estrogen levels.
Used in Cosmetic Industry:
Estradiol-17-stearate is used as an ingredient in anti-aging skincare products. Its estrogenic properties can help improve skin elasticity, reduce wrinkles, and promote a more youthful appearance.
Used in Hormone Research:
Estradiol-17-stearate is used as a research tool in the study of estrogen receptors and their role in various physiological processes. It can help scientists better understand the mechanisms of estrogen action and develop new therapeutic strategies for hormone-related disorders.
Used in Fertility Treatments:
Estradiol-17-stearate is used in fertility treatments to support the development of ovarian follicles and improve the chances of successful conception. It can be administered as part of an assisted reproductive technology (ART) protocol to optimize hormonal balance and promote a favorable environment for fertilization and implantation.

InChI:InChI=1/C36H58O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-35(38)39-34-24-23-33-32-21-19-28-27-29(37)20-22-30(28)31(32)25-26-36(33,34)2/h20,22,27,31-34,37H,3-19,21,23-26H2,1-2H3/t31-,32-,33+,34+,36+/m1/s1

Upstream product

• 14982-15-1 3-benzyloxyestra-1,3,5(10)-trien-17β-ol 
• 112-76-5 Stearoyl chloride 
• 50-28-2 estradiol 
• 126144-03-4 estradiol distearate 

Relevant academic research and scientific papers

Rapid synthesis of long chain fatty acid esters of steroids in ionic liquids with microwave irradiation: Expedient one-pot procedure for estradiol monoesters

We report the rapid synthesis (1 min) in high yield of fatty acid ester (FAE) derivatives of several steroids under microwave irradiation in an ionic liquid (IL). An expedient regioselective hydrolysis at C-3 of estradiol diesters is also reported.

Mass Spectrometric Studies on 17β-Estradiol-17-fatty Acid Esters: Evidence for the Formation of Anion-Dipole Intermediates

The behaviour towards low collision energy processes (eV range) of (1-) prepared under negative ion chemical ionization (NICI) ammonia conditions from 17β-estradiol-17-fatty acid esters has been investigated.From such bifunctional compounds containing two acidic sites (i.e. phenol and ester groups), two isomeric forms (i.e. phenoxide and enolate forms) characterize the (1-) ion structures, whose distribution depends on the ion preparation mode.Here NICI (ammonia) provides both phenoxide and enolate forms as the (1-) species.This behaviour contrasts with the regioselectivity observed for proton abstraction from phenol under NICI (N2O) and fast atom bombardment conditions.Production of both phenoxide and enolate forms in NICI (ammonia) is demonstrated under NICI (ND3) conditions in which DO-labelled d - H>(1-) enolate ions are produced in a similar yield to unlabelled d - D>(1-) phenoxide ions.Collisionally activated dissociation (CAD) spectra of both isomeric deprotonated molecules differ strongly by the presence of two different pairs of complementary daughter ions, suggesting that these ionic species are unconvertible.This is due to a steric hindrance effect on the long-distance proton transfer.A mechanistic investigation on the formation of fragment ion pairs produced under CAD was performed with various deuterium-labelled molecules.From these experiments, evidence is provided for molecular isomerizations into ion-dipole complexes (prior to dissociation) which are structurally dependent on the initial charge location.Direct dissociation of these intermediates competes with the occurence of exothermic proton transfer(s) yielding the formation of other isomeric intermediate forms.The orientation of these proton transfers is dictated by the relative acidities of both moieties of the complex.