82210-23-9Relevant academic research and scientific papers
TRANSFORMED STEROIDS. 123. SYNTHESIS OF 5α(H)- AND 5α(OH)-6-KETOSTEROIDS WITH AN ADDITIONAL 17α,20ξ-DIHYDROXYTETRAHYDROPYRAN RING E
Kamernitskii, A. V.,Levi, V. G.,Reshetova, I. G.,Bogdanov, V. S.,Pavlov, V. A.,Cherepanova, E. G.
, p. 59 - 66 (1982)
The paper is devoted to the synthesis of 3,17α,20-trihydroxy-16β,23-epoxy-21,24-dinor-5αH-cholan-6-one and 3,5α,17α,20-tetrahydroxy-16β,23-epoxy-21,24-dinorcholan-6-one and derivatives of them.It has been shown that the reduction of 3,17α-dihydroxy-16β,23-epoxy-21,24-dinorchol-5-en-20-one with sodium tetrahydroborate and with diborane takes place stereospecifically with different spatial directivities: in the products of diborane reduction, ring E exists in the boat form, as has been shown by 1H and 13C NMR methods.The trans linkage of rings A/B in the modified steroids has been confirmed by their circular dichroism spectra.
