82230-53-3

Basic information

• Product Name: Girisopam
• Synonyms: Girisopam;1-(3-Chlorophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine;1-(3-Chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine;GYKI-51189
• CAS NO: 82230-53-3
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.797
• Mol File: 82230-53-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 453.9°Cat760mmHg
• Flash Point: 228.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 5.34E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: Girisopam(CAS DataBase Reference)
• NIST Chemistry Reference: Girisopam(82230-53-3)
• EPA Substance Registry System: Girisopam(82230-53-3)

Safety Data

• Hazardous Substances Data: 82230-53-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H17ClN2O2/c1-11-7-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-5-4-6-14(19)8-12/h4-6,8-10H,7H2,1-3H3

Upstream product

• 776-99-8 3,4-dimethoxyphenylacetone 
• 535-80-8 3-chlorobenzoate 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 474070-11-6 C₁₇H₁₄Cl₂N₂O₂ 
• 917-54-4 methyllithium 
• 474055-25-9 C₁₈H₁₇ClO₅ 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 104278-22-0 2-(acetonyl)-3'-(chloro)-4,5-di-(methoxy)-benzophenone 
• 866252-52-0 4,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 90140-67-3 3-Acetyl-1-(3-chlorphenyl)-4,5-dihydro-7,8-dimethoxy-4-methylen-3H-2,3-benzodiazepin 
• 90140-68-4 3-Acetyl-1-(3-chlorphenyl)-7,8-dimethoxy-4-methyl-3H-2,3-benzodiazepin 

Relevant articles and documents

Facile synthesis of 2,3-benzodiazepines using one-pot two-step phosphate-assisted acylation-hydrazine cyclization reactions

Here, we report new methodology for synthesizing 2,3-benzodiazepines and their analogues by means of phosphate-assisted acylation reaction of 1-arylpropan-2-ones with a carboxylic acid followed by hydrazine cyclization in a one-pot two-step manner. An unp

One-pot synthesis of 2,3-benzodiazepines from arynes and β-diketones

Novel one-pot synthesis of 2,3-benzodiazepines from aryne precursors was accomplished. Tofisopam, well-known anxiolytics, could be synthesized via C-C bond insertion of 4,5-dimethoxybenzyne with 2-ethyl-1-(3,4-dimethoxyphenyl)- butane-1,3-dione, followed by the reaction with hydrazine hydrate in a one-pot operation. This protocol is applicable to the synthesis of other biologically active 2,3-benzodiazepines, such as Girisopam and Nerisopam.

Process for the preparation of high-purity 1-(3-chloro-phenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine

The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) STR1 in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of