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Usage

Uses

Used in Pharmaceutical Research:
4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is used as a reagent in organic synthesis for the introduction of the triflate group to nucleophiles. This facilitates various chemical reactions such as substitution, elimination, and palladium-catalyzed cross-coupling reactions, which are crucial in the synthesis of complex organic molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate serves as a valuable reagent to modify and functionalize organic compounds. Its ability to introduce the triflate group to nucleophiles aids in the formation of new chemical bonds and the construction of intricate molecular structures.
Used in Other Industries:
Beyond pharmaceutical research and organic synthesis, 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate finds applications in other industries where complex organic molecules are synthesized and utilized. Its versatility as a reagent makes it a valuable tool for advancing chemical research and development.

InChI:InChI=1/C12H17F3O5SSi/c1-18-8-6-10(20-21(16,17)12(13,14)15)11(22(3,4)5)7-9(8)19-2/h6-7H,1-5H3

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1276113-16-6 4,5-dimethoxy-2-trimethylsilylphenol 
• 129103-69-1 2-bromo-4,5-dimethoxyphenol 
• 2033-89-8 3,4-dimethoxyphenol 
• 107-46-0 Hexamethyldisiloxane 

Downstream Products

• 1354348-90-5 (5,6-dimethoxybenzofuran-2-yl)(phenyl)methanone 
• 1309610-72-7 C₂₀H₂₃NO₄ 

Relevant academic research and scientific papers

Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent

Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).

Transition-Metal-Free Benzannulation of Tricarbonyl Derivatives with Arynes: Access to 1,3-Dinaphthol Precursors for the Synthesis of Rhodamine Dye Analogues

Herein, we report a transition-metal-free annulation reaction of benzynes and 1,3-oxopentanedioate for the synthesis of highly functionalized naphthalene derivatives for the first time. Additionally, the representative naphthalene derivatives have been successfully transformed into the new series of rhodamine dye analogues.

Synthesis method of calmodulin inhibitor for treating brain-derived diseases

The invention discloses a synthesis method of a calmodulin inhibitor for treating brain-derived diseases and belongs to the technical field of synthesis of chemicals. The technical scheme is characterized in that a synthetic route of the synthesis method