82231-58-1

Usage

Uses

Used in Organic Synthesis:
Ethyl 2-(4-bromo-1H-pyrazol-1-yl)acetate is utilized as a key intermediate in organic synthesis for the preparation of a range of chemical compounds. Its presence of a bromine atom and pyrazole ring allows for versatile chemical reactions, making it a valuable component in the creation of new molecules with potential applications.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, Ethyl 2-(4-bromo-1H-pyrazol-1-yl)acetate is employed as a building block for the development of pharmaceuticals. Its unique structure contributes to the design of new drugs, potentially leading to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Pharmaceutical Development:
Ethyl 2-(4-bromo-1H-pyrazol-1-yl)acetate is used as a precursor in the synthesis of bioactive molecules for pharmaceutical applications. Its reactivity and structural features are harnessed to create compounds that can target specific biological pathways, offering new avenues for the treatment of various diseases and conditions.
Used in Bioactive Molecule Preparation:
Ethyl 2-(4-broMo-1H-pyrazol-1-yl)acetate is also used in the preparation of bioactive molecules, where its pyrazole and bromine-containing structure can be leveraged to enhance the biological activity of the resulting molecules. This can lead to the development of new drugs with specific mechanisms of action, contributing to advancements in medicine.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 864754-16-5 (4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl)-acetic acid ethyl ester 
• 1042428-74-9 Ethyl [4-(2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyrimidin-5-yl)-1H-pyrazol-1-yl]acetate 

Relevant academic research and scientific papers

PYRROLOTRIAZINE DERIVATIVES FOR TREATING KIT- AND PDGFRA-MEDIATED DISEASES

The present disclosure provides compounds of Formula I, pharmaceutical salts thereof, and/or solvates of any of the foregoing which are useful for treating diseases and conditions related to mutant KIT and PDGFRa and present an advantageously non-brain pe

NON-FUSED TRICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors

A series of 2-amino-N-benzylpyridine-3-carboxnamides, 2-amino-N- benzylpyridine-3-sulfonamides and 2-amino-3-benzylthiopyridines against c-Met were designed by means of bioisosteric replacement and docking analysis. Optimization of the 2-amino-3-benzylthiopyridine scaffold led to the identification of compound (R)-10b displaying c-Met inhibition with an IC 50 up to 7.7 nM. In the cytotoxic evaluation, compound (R)-10b effectively inhibited the proliferation of c-Met addictive human cancer cell lines (IC50 from 0.19 to 0.71 μM) and c-Met activation-mediated cell metastasis. At a dose of 100 mg/Kg, (R)-10b evidently inhibited tumor growth (45%) in NIH-3T3/TPR-Met xenograft model. Of note, (R)-10b could overcome c-Met-activation mediated gefitinib-resistance, which indicated its potential use for drug combination. Taken together, 2-amino-3-benzylthiopyridine scaffold was first disclosed and exhibited promising pharmacological profiles against c-Met, which left room for further exploration.

QUINOLINONE DERIVATIVES

The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.

KINASE INHIBITOR COMPOUNDS

Pyridine and pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Microwave-assisted synthesis of bipyrazolyls and pyrazolyl-substituted pyrimidines

We describe the preparation of 1,4′-bipyrazolyls and 4-pyrazolylpyrimidines by the reaction of 2-pyrazolyl-3-dimethylamino acrylate and acrylonitrile with double nucleophilic reagents such as hydrazines, urea and guanidine. Reactions were performed under microwave irradiation in 5-60 min. This is a useful procedure for the preparation of valuable compounds with applications in medicinal and coordination chemistry.