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1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester, also known as (4-Iodo-pyrazol-1-yl)-acetic acid ethyl ester, is an organic compound with a molecular formula of C7H6N2O2I and a molecular weight of 262.04 g/mol. It features a pyrazole ring with an iodine atom at the 4-position and an ethyl ester group attached to the acetic acid moiety. 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester is a key intermediate in the synthesis of autotaxin inhibitors.

82231-59-2

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82231-59-2 Usage

Uses

Used in Pharmaceutical Industry:
1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester is used as a key intermediate in the synthesis of autotaxin inhibitors for the development of potential therapeutic agents targeting various diseases. Autotaxin is an enzyme involved in the regulation of lysophosphatidic acid (LPA) levels, which plays a crucial role in cell proliferation, migration, and survival. Inhibition of autotaxin can help in the treatment of conditions such as cancer, fibrosis, and neurological disorders by modulating LPA signaling pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 82231-59-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,3 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 82231-59:
(7*8)+(6*2)+(5*2)+(4*3)+(3*1)+(2*5)+(1*9)=112
112 % 10 = 2
So 82231-59-2 is a valid CAS Registry Number.

82231-59-2Downstream Products

82231-59-2Relevant academic research and scientific papers

BTK inhibitor and preparation method and pharmaceutical application thereof

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Paragraph 1001-1009, (2020/12/14)

The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic thereof, and an intermediateand a preparation method thereof, and an application of the compound in BTK related diseases such as tumors or autoimmune system diseases. B-L-K (I).

Pyrazole compound, medicine composition containing pyrazole compound and application

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Paragraph 0284-0288, (2020/03/17)

The invention relates to a pyrazole compound, a medicine composition containing the pyrazole compound and application. The pyrazole compound is of a structure shown in a formula (I) as shown in the description. The compound can be used for inhibiting IRAK

HETEROCYCLIC AUTOTAXIN INHIBITORS AND USES THEREOF

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Page/Page column 104-105, (2013/02/28)

Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other c

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