82235-61-8Relevant academic research and scientific papers
The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells.
Yamashita,Ohta,Kawasaki,Ohta
, p. 1359 - 1362 (2001)
[reaction in text] The first total synthesis of (+/-)-linderol A, a hexahydrodibenzofuran isolated from Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells was achieved via a 20-step of reaction
Visible-Light-Driven Intermolecular [2+2] Cycloadditions between Coumarin-3-Carboxylates and Acrylamide Analogs
Liu, Qiang,Zhu, Fu-Ping,Jin, Xiao-Ling,Wang, Xiao-Ju,Chen, Han,Wu, Li-Zhu
, p. 10326 - 10329 (2015/07/07)
This paper reports a room temperature visible-light-driven protocol for the intermolecular [2+2] cycloadditions between coumarin-3-carboxylates and acrylamides analogs by an energy-transfer process. Using an iridium complex FIrPic as a photosensitizer and a 3W blue LED as a light source, an array of cyclobutabenzocypyranones were prepared in moderate to excellent yields.
Nucleophilic addition reactions on 3-carbethoxy-5,7-dimethoxycoumarin
Hassan,Shiba,Harb,Abou-El-Regal,El-Metwally
, p. 679 - 688 (2007/10/03)
3-Carbethoxy-5,7-dimethoxycoumarin (2) underwent Michael addition and addition-cyclization of some active methylene compounds under different reaction conditions to give the adducts (3-7). Addition of phenylmagnesium bromide onto (2) yielded the tertiary alcohol (8). Addition of ammonia derivatives on (2) afforded the 3-carboxamides (9a-c) and azine (10). Furthermore, alcoholysis and hydrolysis yielded the coumarins (11a-c).
Synthesis of Coumarin-3-O-acylisoureas by Dicyclohexylcarbodiimide
Bonsignore, Leonardo,Cottiglia, Filippo,Maccioni, Anna M.,Secci, Daniela,Lavagna, Silvio M.
, p. 573 - 578 (2007/10/02)
The synthesis and isolation of some O-acylisoureas are described.The reaction between dicyclohexylcarbodiimide and coumarin-3-carboxylic acids leads to coumarin-dicyclohexylisourea derivatives, isolated as the main products, and to coumarin-dicyclohexylur
Reductions via Boranes: A New, Convenient Method for the Preparation of 3-Substituted Esters and Thioesters of 3,4-Dihydrocoumarin
Kirkiacharian, B. S.,Danan, A.
, p. 383 - 385 (2007/10/02)
Reduction of various O-ethyl coumarin-3-carboxylates and O-ethyl coumarin-3-thioncarboxylates with diborane, borane dimethyl sulfide, 9-borabicyclononane, and bisethane-diborane lead to the corresponding 3,4-dihydro derivatives with good yields.
