82239-68-7

Usage

Uses

Used in Cancer Therapy Research:
(-)-CYDIOP is used as a potential therapeutic agent for cancer treatment due to its selective cytotoxicity towards cancer cells while sparing healthy cells. This selective action makes it a subject of interest for further research and development in the field of oncology.
Used in Pharmaceutical Research:
(-)-CYDIOP is used as a research tool in the pharmaceutical industry to study its pharmacological properties and potential applications. (-)-CYDIOP's ability to inhibit calcium ATPase and its toxic effects on cells provide valuable insights into its mechanism of action and possible therapeutic uses.
Used in Food Safety and Toxicology Studies:
(-)-CYDIOP is used in food safety and toxicology studies to understand its role in causing food poisoning and to develop methods for detecting and preventing its contamination in food products. This research is crucial for ensuring the safety of the food supply and protecting public health.
Note: The uses listed above are based on the potential applications of (-)-CYDIOP as described in the provided materials. However, due to its toxicity, any practical application of (-)-CYDIOP must be approached with caution and thorough research to ensure safety and efficacy.

InChI:InChI=1/C31H56O2P2/c1-31(2)32-29(23-34(25-15-7-3-8-16-25)26-17-9-4-10-18-26)30(33-31)24-35(27-19-11-5-12-20-27)28-21-13-6-14-22-28/h25-30H,3-24H2,1-2H3/t29-,30-/m0/s1

Upstream product

• 4141-50-8 1,2-bis(diphenylphosphinoyl)ethane 
• 16527-12-1 C₂₆H₄₈O₂P₂ 
• 94665-49-3 (4R,5R)-4,5-Bis-(dicyclohexyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane 
• 37002-45-2 (4S,5S)-2,2-dimethyl-4,5-bis(p-toluenesulfonyloxymethyl)-1,3-dioxolan 
• 82239-65-4 (+)-(2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-difluorobutane 
• 19966-81-5 lithium dicyclohexylphosphide 

Relevant academic research and scientific papers

FULLY ALKYLATED CHIRAL DIPHOSPHINES, RDIOP, AND THEIR Rh(I) COMPLEXES

Tetraalkyl analogs of DIOP, (-)-EtDIOP, (-)-i-PrDIOP, and (-)-CyDIOP, have been prepared for the first time by the reaction of (+)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-difluorobutane and the corresponding lithium dialkylphosphides.These diphosphines for

Enantioselective Rh-Catalyzed Hydroboration of Silyl Enol Ethers

The asymmetric hydroboration of alkenes has proven to be among the most powerful methods for the synthesis of chiral boron compounds. This protocol is well suitable for activated alkenes such as vinylarenes and alkenes bearing directing groups. However, the catalytic enantioselective hydroboration of O-substituted alkenes has remained unprecedented. Here we report a Rh-catalyzed enantioselective hydroboration of silyl enol ethers (SEEs) that utilizes two new chiral phosphine ligands we developed. This approach features mild reaction conditions and a broad substrate scope as well as excellent functional group tolerance, and enables highly efficient preparation of synthetically valuable chiral borylethers.

Preparation of optically active peralkyldiphosphines and their use, as the rhodium(I) complex, in the asymmetric catalytic hydrogenation of ketones

Two types of the optically active peralkyldiphosphine, 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(dialkylphosphino)butane (Rdiop 3) and N-(N'-substituted carbamoyl)-4-dicyclohexylphosphino-2-dicyclohexylphosphinomethylpyrrolidine (R-Cycapp 8), have been p

NEW ENTRY TO THE PREPARATION OF CHIRAL BIS(DICYCLOHEXYLPHOSPHINO)ALKANE DERIVATIVES. USE FOR RHODIUM-CATALYZED HYDROGENATION OF CARBONYL COMPOUNDS

Conversion has been achieved of two representative chiral diphosphines, (-)-DIOP and (S,S)-Chiraphos, into the corresponding bis(dicyclohexylphosphino)alkane derivatives, the latter being used for chiral ligands of the rhodium(I) catalyst in the homogeneous hydrogenation of prochiral carbonyl compounds.