94665-49-3Relevant academic research and scientific papers
NEW ENTRY TO THE PREPARATION OF CHIRAL BIS(DICYCLOHEXYLPHOSPHINO)ALKANE DERIVATIVES. USE FOR RHODIUM-CATALYZED HYDROGENATION OF CARBONYL COMPOUNDS
Yamamoto, Keiji,Saeed-Ur-Rehman
, p. 1603 - 1606 (1984)
Conversion has been achieved of two representative chiral diphosphines, (-)-DIOP and (S,S)-Chiraphos, into the corresponding bis(dicyclohexylphosphino)alkane derivatives, the latter being used for chiral ligands of the rhodium(I) catalyst in the homogeneous hydrogenation of prochiral carbonyl compounds.
Enantioselective Rh-Catalyzed Hydroboration of Silyl Enol Ethers
Dong, Wenke,Lei, Yaqin,Lin, Zhenyang,Ma, Honghui,Xu, Xin,Zhao, Wanxiang
supporting information, p. 10902 - 10909 (2021/07/31)
The asymmetric hydroboration of alkenes has proven to be among the most powerful methods for the synthesis of chiral boron compounds. This protocol is well suitable for activated alkenes such as vinylarenes and alkenes bearing directing groups. However, the catalytic enantioselective hydroboration of O-substituted alkenes has remained unprecedented. Here we report a Rh-catalyzed enantioselective hydroboration of silyl enol ethers (SEEs) that utilizes two new chiral phosphine ligands we developed. This approach features mild reaction conditions and a broad substrate scope as well as excellent functional group tolerance, and enables highly efficient preparation of synthetically valuable chiral borylethers.
