82244-69-7

Upstream product

• 865-50-9 iodomethane-d3 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 811-98-3 d⁽⁴⁾-methanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1380035-79-9 C₂₀H₁₇⁽²⁾HO₃S 
• 3185-99-7 Methyl p-tolyl sulfone 

Relevant academic research and scientific papers

Method for synthesizing deuterated dimethylamine salt with deuterated methanol

The invention discloses a method for synthesizing a deuterated dimethylamine salt by using deuterated methanol. The method comprises the following steps: (1) carrying out a reaction on a compound 1 with a sulfonyl chloride compound to obtain a compound 2; (2) carrying out a reaction on the compound 2 with R2-NH2 to obtain a compound 3; and (3) carrying out a reaction on the compound 3 with an acidto obtain the deuterated dimethylamine salt. The preparation method provided by the invention is simple and efficient, and has a good industrial application prospect.

Effect of chiral diene ligands in rhodium-catalyzed asymmetric addition of arylboronic acids to α,β-unsaturated sulfonyl compounds

Asymmetric addition of arylboronic acids to α,β-unsaturated sulfonyl compounds proceeded in the presence of a rhodium catalyst coordinated with a chiral diene ligand to give high yields of the addition products with high enantioselectivity (96->99.5% ee). The diene ligand was proved to be essential for the formation of the addition products, while the use of a bisphosphine ligand mainly gave the cine-substitution product.