82251-69-2Relevant academic research and scientific papers
Esterification of Carboxylic Acids with Alcohols Using Benzenesulphonyl and Methanesulphonyl Chlorides
Dharmaratne, H. R. W.,Gunatilaka, A. A. Leslie,Sotheeswaran, S.
, p. 39 - 41 (2007/10/02)
The role of benzene- and methane-sulphonyl chlorides as coupling agents in the esterification of carboxylic acids with alcohols has been investigated.Hindered tertiary alcohols require initial conversion of the acid to the mixed acid-anhydride with benzenesulphonyl chloride.It is necessary to adjust molar ratios for esterification with secondary alcohols so that the intermediate formed is the symmetrical acid anhydride, since mixed acid-anhydrides also give the sulphonates of the alcohols wihich are difficult to separate from the esters.
