82251-86-3

Upstream product

• 63-91-2 L-phenylalanine 
• 158556-65-1 4-nitrophenyl (4-nitrophenyl)methyl carbonate 
• 71731-66-3 4-nitrobenzyl carbonazidate 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 63-91-2 L-phenylalanine 

Relevant academic research and scientific papers

Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp2)-H Bonds

The first example of the Pd(II)-catalyzed enantioselective amination of aryl C-H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.

Reduction and pH dual-responsive block copolymers containing pendent p-nitrobenzyl carbamate functionalities: Synthesis and self-assembly behavior

We report on the preparation of reduction-responsive amphiphilic block copolymers containing pendent p-nitrobenzyl carbamate (pNBC)-caged primary amine moieties by reversible addition–fragmentation chain transfer (RAFT) radical polymerization using a poly

p-Nitrobenzyloxycarbonyl (pNZ) as a temporary Na-protecting group in orthogonal solid-phase peptide synthesis - Avoiding diketopiperazine and aspartimide formation

p-Nitrobenzyloxycarbonyl (pNZ) was used as a temporary protecting group for α-amino functionalities in solid-phase peptide synthesis. The corresponding derivatives are readily synthesized solids that perform well on solid phase. The pNZ moiety is orthogonal with the most common protecting groups used in peptide chemistry, and is removed under neutral conditions in the presence of catalytic amounts of acid. The use of pNZ derivatives in conjunction with Fmoc chemistry circumvents typical side reactions associated with the use of piperidine, such as DKP and aspartimide formation. The flexibility of pNZ can be exploited for the preparation of libraries of small organic molecules. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.