82258-76-2

Usage

Uses

Used in Chemical Synthesis:
Benzene, 1-(3-chloropropyl)-3-(trifluoroMethyl)is used as a chemical intermediate in the synthesis of various organic compounds. Its unique structure with a chloropropyl and trifluoromethyl group attached to the benzene ring makes it a valuable building block for creating a range of specialty chemicals and pharmaceuticals.
Used in Solvent Applications:
Benzene, 1-(3-chloropropyl)-3-(trifluoroMethyl)serves as a solvent in certain industrial processes due to its ability to dissolve a wide range of substances. Its solubility properties are particularly useful in the production of coatings, adhesives, and elastomers, where it can facilitate the mixing and application of these materials.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Benzene, 1-(3-chloropropyl)-3-(trifluoroMethyl)is utilized as a starting material for the development of new drugs. Its chemical properties allow for the creation of novel molecular entities that can target specific biological pathways, potentially leading to the discovery of new therapeutic agents.
Used in Agrochemical Industry:
Benzene, 1-(3-chloropropyl)-3-(trifluoroMethyl)is also employed in the agrochemical industry, where it is used as a precursor in the synthesis of various pesticides and herbicides. Its role in these applications is to provide the necessary functional groups for the development of effective and targeted agrochemicals.

Upstream product

• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 109-70-6 1.3-chlorobromopropane 
• 325142-82-3 4,4,5,5-tetramethyl-2-(3-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane 

Downstream Products

• 226256-56-0 cinacalcet 
• 364782-34-3 cinacalcet hydrochloride 

Relevant academic research and scientific papers

Iron-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions between Alkyl Halides and Unactivated Arylboronic Esters

An iron-catalyzed cross-coupling reaction between alkyl halides and arylboronic esters was developed that does not involve activation of the boronic ester with alkyllithium reagents nor requires magnesium additives. A combination of experimental and theoretical investigations revealed that lithium amide bases coupled with iron complexes containing deprotonated cyanobis(oxazoline) ligands were best to obtain high yields (up to 89%) in catalytic cross-coupling reactions. Mechanistic investigations implicate carbon-centered radical intermediates and highlight the critical importance of avoiding conditions that lead to iron aggregates. The new iron-catalyzed Suzuki-Miyaura reaction was applied toward the shortest reported synthesis of the pharmaceutical Cinacalcet.

PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE

Processes for preparing cinacalcet are provided.

Phenalkoxyalkyl- and phenoxyalkyl-substituted oxiranecarboxylic acids, their use and medicaments containing them

Phenalkoxyalky- and phenoxyalkyl-substituted oxiranecarboxylic acids of the formula STR1 wherein R1 denotes a hydrogen atom (--H), a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group or a trifluoromethyl group, R2 has one of the meanings of R1, R3 denotes a hydrogen atom (--H) or a lower alkyl group, Y denotes --O--(CH2)m --, m denotes O or an integer from 1 to 4, and n denotes an integer from 2 to 8, with the proviso that the sum of m and n is an integer from 2 to 8, and the salts of the acids are new compounds. They display a hypoglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds and of the intermediate products required for their preparation are described.