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Usage

Uses

Used in Pharmaceutical Industry:
[(AMINOCARBONYL)AMINO](PHENYL)ACETIC ACID is used as a building block for the synthesis of various pharmaceuticals. Its presence of both amino and carboxyl groups allows for the creation of a wide range of organic molecules, making it a valuable intermediate in drug development.
Used in Agrochemical Industry:
In the agrochemical industry, [(AMINOCARBONYL)AMINO](PHENYL)ACETIC ACID is used as a starting material for the production of herbicides and insecticides. Its chemical properties and reactivity contribute to the development of effective and targeted agricultural chemicals.
Used in Chemical Reactions and Processes:
Due to its solubility in organic solvents and the presence of functional groups, [(AMINOCARBONYL)AMINO](PHENYL)ACETIC ACID is used as a versatile component in various chemical reactions and processes, facilitating the synthesis of a broad spectrum of organic molecules for different applications.

Upstream product

• 89-24-7 5-phenylimidazolidine-2,4-dione 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 1074-12-0 phenylglyoxal hydrate 
• 57-13-6 urea 
• 7732-18-5 water 
• 88169-89-5 2-phenyl-2-ureidoacetonitrile 
• 100647-18-5 2-phenyl-2-ureidoacetamide 
• 201230-82-2 carbon monoxide 
• 100-52-7 benzaldehyde 
• 590-28-3 potassium cyanate 
• 2835-06-5 phenylglycin 

Downstream Products

• 2935-35-5 (S)-2-phenylglycine 
• 1562661-28-2 C₂₂H₂₂N₂O₅ 
• 5616-20-6 (-)-2-phenyl-2-ureidoacetic acid 
• 875-74-1 (R)-phenylglycine 
• 89-24-7 5-phenylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of substituted hydantoins - A new carbonylation reaction for the synthesis of amino acid derivatives

One-step synthesis of substituted hydantoins can be achieved by the palladium-catalyzed 'ureidocarbonylation' of aldehydes with urea derivatives and carbon monoxide [Eq. (1)]. This surprisingly selective protocol converts substituted ureas into 1,5- and 1,3,5-substituted hydantoins in yields of up to 93 %.

Synthesis of Optically Active Spirohydantoins by Asymmetric Induction. Hydantoin Formation from Amino Nitriles and Chlorosulfonyl Isocyanate

Conversion of 6-chloro- or 6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one with optically active (S)-α-methylbenzylamine in the presence of TiCl4 to the ketimine followed by treatment in EtOH with HCN gas gives excellent yields of crystalline, enantiomerically pure (4S)-4-cyano-2,3-dihydro-6-chloro(or 6-fluoro)-4--4H-1-benzopyran.These sterically hindered amino nitriles react smoothly with chlorosulfonyl isocyanate to give, after hydrolysis, the hydantoins (4S)-2,3-dihydro-6-chloro(or 6-fluoro)-3'-spiro-2',5'-dione.The α-methylbenzyl groups can be removed by aqueous HBr/acetic acid to give the unprotected spirohydantoins.