823-39-2

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dimethyl-2-pyridinamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key building block in the development of new drugs with potential therapeutic applications.
Used in Biochemical Research:
In the field of biochemical research, 3,4-Dimethyl-2-pyridinamine is used as an inhibitor of human nitric oxide synthase (NOS). Nitric oxide synthase is an enzyme responsible for the production of nitric oxide, a molecule with various physiological roles, including vasodilation, neurotransmission, and immune response. By inhibiting this enzyme, researchers can study the effects of nitric oxide on different biological processes and develop potential therapeutic agents targeting NOS-related diseases.
Used in Chemical Synthesis:
3,4-Dimethyl-2-pyridinamine can also be used as a starting material or intermediate in the synthesis of various organic compounds, including agrochemicals, dyes, and other specialty chemicals. Its reactivity and functional groups make it a valuable component in the development of new chemical entities with diverse applications.

Upstream product

• 583-58-4 3,4-Lutidin 
• 121-69-7 N,N-dimethyl-aniline 
• 1233519-99-7 bis(1,1-dimethylethyl) (3,4-dimethyl-2-pyridinyl)imidodicarbonate 
• 695-34-1 2-Amino-4-methylpyridine 
• 1796-86-7 3,4-dimethylpyridine 1-oxide 

Downstream Products

• 65169-34-8 3,4-dimethyl-2-hydroxy-5-nitropyridine 
• 1181575-02-9 N-tert-butylcarbonylleucinol 
• 145149-48-0 tert-butyl 1-hydroxy-3-phenylpropan-2-ylcarbamate 
• 149897-61-0 5-(2-carboxybenzoyloxy)-4-methoxy-2,6,6-trimethyl-2-cyclohepten-1-one 
• 583-58-4 3,4-Lutidin 
• 183142-47-4 5-benzyloxy-3-cyano-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran 
• 179555-37-4 2-acetamido-4,5-dimethylpyridine 
• 183736-47-2 7-butyryloxy-3-carboxy-6-chlorocoumarin 

Relevant academic research and scientific papers

PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS

This invention relates to imidazopyridylmethylene substituted piperidine derivatives orexin antagonists and their use as pharmaceuticals.

Synthesis of two potential heterocyclic amine food mutagens

(Chemical Equation Presented) The syntheses of two potential food mutagens formed during cooking, 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-b]pyridine (1) and 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-c]pyridine (2), are described.

2-Aminopyridine and 2-pyridone C-nucleosides, oligonucleotides comprising, and tests using the same oligonucleotides

The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation through triplex binding.

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.

Substituted 2-aminopyridines as inhibitors of nitric oxide synthase

Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. STR1

Metal-Chelating 1,3-bis(2'-Pyridylimino)isoindolines

A variety of novel chelating 1,3-bis(2'-pyridylimino)isoindoline ligands were prepared and characterized including ligands substituted on both the pyridyl and isoindoline ring systems.Noteworthy are the first isoindoline ligands with solubility in aqueous media.A convenient preparation of 4-alkoxyphthalonitriles is reported; these compounds are readily obtained from 4-nitrophthalonitrile and are suitable starting materials for alkoxy-substituted ligands.

Process for producing azasulfonium salts and rearrangement thereof to thio-ethers

Preparing ortho-substituted anilines by reacting an N-chloroaniline with a non-carbonylic di-hydrocarbon sulfide to form an azasulfonium chloride, reacting the azasulfonium chloride with a strong base to form an aniline substituted in the 2-position with a hydrocarbon-S-hydrocarbyl thio-ether group. The ortho-substituted thio-ether compounds can be reduced with a de-sulfurizing reducing agent such as Raney nickel or the like to form the ortho-alkylated aniline. The aniline may be an amino-pyridine. The azasulfonium salt and thio-ether intermediate products can be isolated and recovered. If desired, the thio-ether compounds can be reduced to form ortho-alkylated aniline products which are useful as intermediates for a wide variety of purposes, including their uses in making dyes, herbicides, and the like.