82317-75-7

Basic information

• Product Name: Tyrosine, N-acetyl-3,5-dimethoxy-O-methyl-, methyl ester
• CAS NO: 82317-75-7
• Molecular Formula: C15H21NO6
• Molecular Weight: 311.335
• Mol File: 82317-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Tyrosine, N-acetyl-3,5-dimethoxy-O-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tyrosine, N-acetyl-3,5-dimethoxy-O-methyl-, methyl ester(82317-75-7)
• EPA Substance Registry System: Tyrosine, N-acetyl-3,5-dimethoxy-O-methyl-, methyl ester(82317-75-7)

Safety Data

• Hazardous Substances Data: 82317-75-7(Hazardous Substances Data)

Upstream product

• 92249-24-6 2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone 
• 18111-19-8 Diethyl-α-acetamido-α-<3,4,5-trimethoxy-benzyl>-malonat 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 67-56-1 methanol 
• 82337-59-5 N-Acetyl-3.4.5-trimethoxyphenylalanin 

Downstream Products

• 82317-78-0 (R)-methyl 2-acetamido-3-(3,4,5-trimethoxyphenyl)propanoate 
• 18111-20-1 (S)-2-acetamido-3-(3,4,5-trimethoxyphenyl)propanoic acid 
• 51221-30-8 (R)-2-Amino-3-(3,4,5-trimethoxy-phenyl)-propionic acid; hydrochloride 
• 82317-85-9 (R)-2-((tert-butoxycarbonyl)amino)-3-(3,4,5-trimethoxyphenyl)propanoic acid 

Relevant articles and documents

Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer–Hexamer Assembly

The proteolytic complex ClpXP is fundamental to bacterial homeostasis and pathogenesis. Because of its conformational flexibility, the development of potent ClpXP inhibitors is challenging, and novel tools to decipher its intricate regulation are urgently needed. Herein, we present amino acid based phenyl esters as molecular probes to study the activity and oligomerization of the ClpXP complex of S. aureus. Systematic screening of (R)- and (S)-amino acids led to compounds showing potent inhibition, as well as stimulation of ClpXP-mediated proteolysis. Substoichiometric binding of probes arrested ClpXP in an unprecedented heptamer–hexamer assembly, in which the two heptameric ClpP rings are dissociated from each other. At the same time, the affinity between ClpX and ClpP increased, leading to inhibition of both enzymes. This conformational arrest is beneficial for the consolidated shutdown of ClpXP, as well as for the study of the oligomeric state during its catalytic cycle.

Synthesis and biological activity of some very hydrophobic superagonist analogues of luteinizing hormone-releasing hormone

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