823182-34-9Relevant academic research and scientific papers
5-Phenylthio-1,3-oxazinan-4-ones via hetero Diels-Alder reactions: synthesis of (R)- and (S)-Duloxetines and Fluoxetines
Panunzio, Mauro,Tamanini, Emiliano,Bandini, Elisa,Campana, Eileen,D'Aurizio, Antonio,Vicennati, Paola
, p. 12270 - 12280 (2007/10/03)
The synthesis of 5-phenylthio-1,3-oxazinan-4-ones, through a hetero Diels-Alder strategy, is described. The cycloadducts thus prepared have been shown to be useful intermediates for the synthesis of 1,3-aminoalcohols, valuable intermediates in the preparation of biologically significant molecules, e.g., optically active Duloxetines and Fluoxetines. In the course of this elaboration a novel microwave assisted desulfurization reaction is reported.
Synthesis of enantiomerically pure (S)- and (R)-fluoxetine (Prozac) via a hetero Diels-Alder strategy
Panunzio, Mauro,Rossi, Katia,Tamanini, Emiliano,Campana, Eileen,Martelli, Giorgio
, p. 3489 - 3493 (2007/10/03)
A new route to enantiomerically pure (R)- and (S)-fluoxetine is described using a hetero Diels-Alder strategy.
