823189-68-0

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinecarboxamide, N-methoxy-N-methylis used as a building block for the synthesis of various drugs and pharmaceuticals. Its presence as an intermediate in the preparation of numerous bioactive molecules makes it an important component in drug development.
Used in Scientific Research:
5-Pyrimidinecarboxamide, N-methoxy-N-methylis also used as a research chemical in scientific studies and experiments. Its unique structure allows researchers to explore its properties and potential applications in various fields of chemistry and biology.

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 201230-82-2 carbon monoxide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 15226-74-1 dicobalt octacarbonyl 
• 4595-61-3 pyrimidine-5-carboxylic acid 

Downstream Products

• 103686-55-1 (4-chlorophenyl)(pyrimidin-5-yl)methanone 
• 1600565-49-8 (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyrimidin-5-yl)methanol 

Relevant academic research and scientific papers

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases disorders or symptoms thereof mediated by such metalloenzymes.

One-Pot Direct Synthesis of Weinreb Amides from Aryl and Hetero Aryl Halides Using Co 2(CO) 8 as an Effective CO Source under Conventional Thermal Heating

A successful protocol for the synthesis of Weinreb amides directly from aryl halides via aminocarbonylation with N,O-dimethyl hydroxylamine using Co2(CO)8 as an in situ CO source has been demonstrated. The effects of various reaction parameters such as temperature, base, and CO source have also been investigated and optimized. GRAPHICAL ABSTRACT.

HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling

Heterogeneously catalysed carbonylative coupling reactions such as aminocarbonylation and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for efficient and environmentally attractive synthesis of Weinreb amides and ketones from aryl bromides or iodides. The catalyst is air stable, offers high activity with very low palladium leaching and is recyclable. The presence of a phosphine ligand was required when aryl bromides were used as substrates, while no ligand was necessary when aryl iodides were used. the Partner Organisations 2014.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.