823219-89-2

Usage

Derivative of 3-isoxazolecarboxylic acid

ethyl ester

Contains

thioether group and isopropyl-phenyl group

Use

pharmaceuticals and organic synthesis

Biological activity

possible

Handle with care and caution

potential impact on human health and environment

Upstream product

• 6262-87-9 2-isopropylbenzenethiol 
• 84654-29-5 5-(bromomethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 

Downstream Products

• 823220-23-1 5-(2-isopropyl-benzenesulfonylmethyl)-isoxazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

ISOXAZOLES AS PEPTIDE DEFORMYLASE INHIBITORS

Isoxazole compounds of formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other disease in which peptide deformylases are involved, especially in t

Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

The synthesis and initial in vitro evaluation of isoxazole-3-hydroxamic acid derivatives as a new class of PDF inhibitors are reported. A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.