82326-69-0Relevant academic research and scientific papers
Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
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, (2008/06/13)
Boronic acid adducts of technetium-99m and radioactive rhenium dioxime complexes, each of which include biochemically active groups, are useful as diagnostic and therapeutic agents, respectively.
Synthesis of the Four Stereoisomers of 1-Azabicyclooct-3-yl-α-hydroxy-α-(4-phenylboronic acid)-α-phenylacetae (QNB-Boronic acid), including a preparative HPLC method to separate diastereoisomeric mixtures with high optical purity
Nanjappan, P.,Ramalingam, K.,Nowotnik, D. P.
, p. 1271 - 1282 (2007/10/02)
The four stereoisomers of 1-azabicyclooct-3-yl-α-hydroxy-α-(4-phenylboronic acid)-α-phenylacetate (QNB boronic acids, 1a-1d) were synthesized initially via 1-azabicyclooct-3-yl-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate (iodo-QNBs, 6a-6d) using an adaptation of a published procedure.The number of steps involved were reducted substantially using a distinctly different approach.This involved the synthesis of diastereoisomers of QNB-boronic acid, followed by separation and isolation of enantiomers by preparative reversed-phase HPLC.An improved method of synthesis of α-hydroxy-α-(4-aminophenyl)-α-phenyl-acetic acid (3a and 3b) from α-hydroxy-α-(4-nitrophenyl)-α-phenylacetic acid (2a and 2b) is also described.
Analogues of 3-Quinuclidinyl Benzilate
Rzeszotarski, W. J.,Gibson, R. E.,Eckelman, W. C.,Simms, D. A.,Jagoda, E. M.,et al.
, p. 1103 - 1106 (2007/10/02)
A number of analogues of 3-quinuclidinyl benzilate (QNB) have been synthesized and their affinities to muscarinic receptor from rat or dog ventricular muscle measured.We have determined that the muscarinic receptor can to a different degree accomodate either a halogen in the ortho, meta, or para position of one phenyl ring or the repalcement of one phenyl ring with an alkyl group.Our in vitro competition studies show that the affinities lie within a 270-fold range, from the highest affinity compound, 3-quinuclidinyl α-hydroxy-α-cyclopentylphenylacetate (2), to the lowest affinity compound, 3-quinuclidinyl α-hydroxy-α-2-propargylphenylacetate (11).
