82359-83-9Relevant academic research and scientific papers
NEW BENZYNE APPROACH TO THE SYNTHESIS OF DEHYDROAPORPHINES, 4,5-DIOXOAPORPHINES AND ARISTOLACTAMS
Castedo, Luis,Guitian, Enrique,Saa, Jose M.,Suau, Rafael
, p. 457 - 458 (1982)
A new strategy for the synthesis of some aporphinoid alkaloids is described.It is based on the intermolecular Diels-Alder cyclization between benzyne and an appropriate methylene isoquinoline derivative.
A new approach to the synthesis of aristolactams. Total synthesis of cepharanone A and B
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Lebrun, Stéphane
, p. 1475 - 1477 (2007/10/03)
An efficient, concise and tactically new synthesis of aristolactams is described. The key step is the aryne-mediated cyclization of an amino carbanion derived from a phosphorylated halobenzamide derivative. Horner reaction, radical cyclization and ultimate deprotection complete the synthesis of the phenanthrene lactam alkaloids. The viability of the strategy is further illustrated by the synthesis of cepharanone A and B.
