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Upstream product

• 2935-35-5 (S)-2-phenylglycine 
• 20989-17-7 (2S)-2-phenylglycinol 
• 95-51-2 o-chloroaniline 
• 62926-91-4 N-(2-chlorophenyl)-2,2,2-trifluoro-acetamide 
• 203861-17-0 ((S)-2-Hydroxy-1-phenyl-ethyl)-carbamic acid phenyl ester 
• 203861-16-9 Methanesulfonic acid (S)-2-phenoxycarbonylamino-2-phenyl-ethyl ester 
• 823786-78-3 N-(2-chloro-4-sulfamoyl-phenyl)-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

Novel diarylsulfonylurea derivatives as potent antimitotic agents

Novel diarylsulfonylurea derivatives have been synthesized and identified as potent inhibitors of tubulin polymerization and cancer cell proliferation. Furthermore, these compounds were also efficacious against multidrug-resistant cancer cells. A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.