823797-72-4Relevant academic research and scientific papers
Direct Decarboxylative Functionalization of Carboxylic Acids via O-H Hydrogen Atom Transfer
Na, Christina G.,Ravelli, Davide,Alexanian, Erik J.
supporting information, p. 44 - 49 (2020/01/22)
Decarboxylative functionalization via hydrogen atom transfer offers an attractive alternative to standard redox approaches to this important class of transformations. Herein, we report a direct decarboxylative functionalization of aliphatic carboxylic acids using N-xanthylamides. The unique reactivity of amidyl radicals in hydrogen atom transfer enables decarboxylative xanthylation under redox-neutral conditions. This platform provides expedient access to a range of derivatives through subsequent elaboration of the xanthate group.
Generation and intermolecular capture of cyclopropylacyl radicals
Heinrich, Markus R.,Zard, Samir Z.
, p. 4969 - 4972 (2007/10/03)
(Chemical Equation Presented) Cyclopropylacyl radicals derived from S-cyclopropylacyl xanthates (dithiocarbonates) undergo intermolecular additions to olefins without loss of CO or ring opening. In the presence of a phenyl ring on carbon C-1 of the cyclopropane ring, loss can be made to occur in the absence of an olefinic trap. The adducts from the cyclopropylacyl radical additions are easily converted into enones by base-induced β-elimination of the xanthate group.
