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Usage

Uses

Used in Pharmaceutical Industry:
5-[(1E)-2-(4-Chlorophenyl)ethenyl]-1,3-benzenediol is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex organic compounds, contributing to the development of new medications.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 5-[(1E)-2-(4-Chlorophenyl)ethenyl]-1,3-benzenediol serves as a key intermediate, facilitating the creation of a variety of organic compounds for research and industrial applications.

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 106120-04-1 5-bromoresorcinol 
• 39192-49-9 3,5-diacetoxybenzoyl chloride 
• 1032508-03-4 (E)-5-[2-(4-chlorophenyl)ethenyl]-1,3-dimethoxyphenylethene 
• 192182-54-0 3,5-dimethoxyphenylboronic acid 

Relevant academic research and scientific papers

Resveratrol derivative and application thereof

The invention provides a resveratrol derivative shown as a formula (II), in the formula (II), when R1 is hydroxyl, halogen, C1-C4 alkyl or C1-C4 methoxy, R2 is H; when R1 is H, R2 is halogen; and particularly, when R1 is hydroxyl, halogen, C1-C4 alkyl or C1-C4 methoxy, R2 is H preferably. According to the new compound resveratrol derivative and the preparation method thereof, the operation processis simple, raw material sources are commercialized and easy to obtain, and compared with resveratrol and 7-hydroxy coumarin, the inhibition effect is remarkably improved. Compared with the previous resveratrol modification method, the method has the advantages that the reaction is completed in one step, and is more direct, efficient and rapid.

Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor

A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC). Compound 4z (HUHS029) exhibited higher inhibitory activity than resveratrol with an IC50 value of 16.1?μM. The activity of 4z on TRPA1 was confirmed in TRPA1-expressing HEK293 cells, as well as in rat dorsal root ganglia neurons by a whole cell patch clamp recording. Furthermore, pretreatment with 4z exhibited an analgesic effect on AITC-evoked TRPA1-related pain behavior in vivo.

A facile and rapid access to resveratrol derivatives and their radioprotective activity

A facile and rapid access to resveratrol derivatives has been achieved based on palladium-catalyzed oxidative Heck reaction of aryl boronic acids with styrenes followed by demethylation in moderate to good yields. A series of resveratrol derivatives with various functional groups has been synthesized easily. The radioprotective activity of synthesized compounds has also been evaluated using rat thymocytes. The results revealed that some resveratrol derivatives efficiently protected the thymocytes from radiation-induced apoptosis.