82387-82-4Relevant academic research and scientific papers
Selective Oxidative Cleavage of 3-Methylindoles with Primary Amines Affording Quinazolinones
He, Junhui,Dong, Jianyu,Su, Lebin,Wu, Shaofeng,Liu, Lixin,Yin, Shuang-Feng,Zhou, Yongbo
supporting information, p. 2522 - 2526 (2020/04/09)
A selective functionalization of C-C-C bonds toward N-C-O bonds is realized by an n-Bu4NI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones in good to excellent yields.
Copper-Catalyzed Oxidative Multicomponent Annulation Reaction for Direct Synthesis of Quinazolinones via an Imine-Protection Strategy
Liang, Yantang,Tan, Zhenda,Jiang, Huanfeng,Zhu, Zhibo,Zhang, Min
supporting information, p. 4725 - 4728 (2019/06/17)
Via an imine-protection strategy, we herein present an unprecedented copper-catalyzed oxidative multicomponent annulation reaction for direct synthesis of quinazolinones. The construction of various products is achieved via formation of three C-N and one
A Domino Process for the Sustainable Synthesis of Quinazolin-4(3 H)-ones with Direct Chemo- and Regioselective Bromination
Sheikhi, Ehsan,Adib, Mehdi,Yazzaf, Rozita,Jahani, Mehdi,Ghavidel, Mehdi
supporting information, p. 2046 - 2050 (2018/09/18)
An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3 H)-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K 2 CO 3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner.
Vilsmeier Reagent: An efficient reagent for the transformation of 2-aminobenzamides into quinazolin-4(3 h)-one derivatives
Farzipour, Soghra,Saeedi, Mina,Mahdavi, Mohammad,Yavari, Hossein,Mirzahekmati, Mohammadreza,Ghaemi, Nasser,Foroumadi, Alireza,Shafiee, Abbas
, p. 481 - 487 (2014/01/23)
Clean and easy preparation of quinazolin-4(3H)-one derivatives using 2-aminobenzamides and Vilsmeier reagent is described. 2-Aminobenzamides were converted into the corresponding quinazolinones under mild and efficient conditions, in good yields without undesirable by-products.
Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives
Gravier,Dupin,Casadebaig,Hou,Boisseau,Bernard
, p. 91 - 94 (2007/10/02)
Some new 4-quinazolinones were prepared. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by ADP, collagen, arachidonic acid and the platelet serotonin release reaction. Most molecules showed an inhibiting power similar to that of acetylsalicylic acid under the same conditions, and even greater when aggregation was induced by ADP. Reduction of the 4-quinazolinone derivatives to their 1,2,3,4-tetrahydroquinazoline homologues produced an increase in platelet inhibitory action except when ADP is the inductor.
Synthesis and in vitro study of platelet antiaggregant activity of 1,2,3,4-tetrahydroquinazoline derivatives
Gravier,Dupin,Casadebaig,Hou,Boisseau,Bernard
, p. 531 - 535 (2007/10/02)
Some original 3-substituted 1,2,3,4-tetrahydroquinazolines were synthesized. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by the main inducers (ADP, collagen, arachidonic acid), platelet serotonin release reaction and thromboxane A2 synthesis. All these molecules possess an inhibiting power which, compared to that of aspirin in the same conditions, is the same or greater when aggregation is induced by ADP.
