82387-83-5Relevant academic research and scientific papers
Selective Oxidative Cleavage of 3-Methylindoles with Primary Amines Affording Quinazolinones
He, Junhui,Dong, Jianyu,Su, Lebin,Wu, Shaofeng,Liu, Lixin,Yin, Shuang-Feng,Zhou, Yongbo
supporting information, p. 2522 - 2526 (2020/04/09)
A selective functionalization of C-C-C bonds toward N-C-O bonds is realized by an n-Bu4NI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones in good to excellent yields.
Pd/Fe3O4 supported on nitrogen-doped reduced graphene oxide for room-temperature isocyanide insertion reactions
Singh, Karandeep,Singh, Ajay K.,Singh, Devendra,Singh, Rakhi,Sharma, Siddharth
, p. 3723 - 3726 (2016/06/14)
A versatile Pd/Fe3O4 supported on N-doped reduced graphene oxide (N-rGO) catalyst was developed to carry out the synthesis of quinazolinones and phenanthridines under extremely mild conditions through isocyanide insertion cascades. T
Synthesis, anti-microbial and molecular docking studies of quinazolin-4(3H)-one derivatives
Mabkhot, Yahia Nasser,Al-Har, Munirah S.,Barakat, Assem,Aldawsari, Fahad D.,Aldalbahi, Ali,Ul-Haq, Zaheer
, p. 8725 - 8739 (2014/08/05)
In this work, synthesis, antimicrobial activities and molecular docking studies of some new series of substituted quinazolinone 2a-h and 3a-d were described. Starting form 2- Aminobenzamide derivatives 1, a new series of quinazolinone derivatives has been
Highly efficient four-component synthesis of 4(3H)-quinazolinones: Palladium-catalyzed carbonylative coupling reactions
He, Lin,Li, Haoquan,Neumann, Helfried,Beller, Matthias,Wu, Xiao-Feng
supporting information, p. 1420 - 1424 (2014/03/21)
Given the importance of quinazolinones and carbonylative transformations, a palladium-catalyzed fourcomponent carbonylative coupling system for the synthesis of diverse 4(3H)-quinazolinone in a concise and convergent fashion has been developed. Starting from 2-bromoanilines (1 mmol), trimethyl orthoformate (2 mmol), and amines (1.1 mmol), under 10 bar of CO, the desired products were isolated in good yields in the presence of Pd(OAc)2 (2 mol%), BuPAd2 (6 mol%) in 1,4-dioxane (2 mL) at 1008C, using N,Ndiisopropylethylamine (2 mmol) as the base. Notably, the process tolerates the presence of various reactive functional groups and is very selective for quinazolinones, and was used in the synthesis of the precursor to the bioactive dihydrorutaempine.
NMR studies of 3-substituted quinazolin-4(3H)-ones
Georgescu, Florentina,Georgescu,Caproiu, Miron T.,Draghici, Constantin
, p. 341 - 350 (2007/10/03)
3-Phenacyl-, 3-methylnaphthoyl-, 3-methylphenacyl- and 3-benzylquinazolin-4(3H)-one derivatives were synthesized and their 1H-NMR, 13C-NMR spectra were recorded. The chemical shifts and the coupling constants are reported.
Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives
Gravier,Dupin,Casadebaig,Hou,Boisseau,Bernard
, p. 91 - 94 (2007/10/02)
Some new 4-quinazolinones were prepared. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by ADP, collagen, arachidonic acid and the platelet serotonin release reaction. Most molecules showed an inhibiting power similar to that of acetylsalicylic acid under the same conditions, and even greater when aggregation was induced by ADP. Reduction of the 4-quinazolinone derivatives to their 1,2,3,4-tetrahydroquinazoline homologues produced an increase in platelet inhibitory action except when ADP is the inductor.
