82393-41-7

Upstream product

• 72297-08-6 3-cis-nonene-1-yl-p-toluenesulfonate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 73466-12-3 Leukotriene A₄ methyl ester 
• 73958-09-5 Phosphorane of (Z)-3-nonen-1-yl-triphenylphosponium bromide 
• 90486-45-6 (Z,Z)-3,6-dodecadienyl p-toluenesulfonate 
• 125197-91-3 3,6-dodecadienyltriphenylphosphonium p-toluenesulfonate 

Relevant academic research and scientific papers

Leukotriene antagonists

Leukotriene antagonists are disclosed comprising compounds having the general formula represented by the formula shown below, esters, amides and physio-logically acceptable salts thereof. These compounds retain the natural 5(S) 6(R) configuration, the 5-hydroxyl group and the natural unsaturated tail with the peptide replaced by a substituted aromatic nucleus linked via a sulfur or oxygen substituent linking a substituent to the 6 position.

SYNTHESIS OF THE 7-CIS ISOMER OF THE NATURAL LEUKOTRIENE D4

Methyl 5(S),6(S)-oxido-11-oxo-7-cis-9-trans-undecadienoate 5 was prepared and used for the synthesis of the novel 7-cis-LTD4 (9) as well as, after isomerization to the all-trans dienal ester 3, for that of the natural leukotrienes.