90486-45-6Relevant academic research and scientific papers
Design, Synthesis, and 5-Lipoxygenase-Inhibiting Properties of 1-Thio-Substiuted Butadienes
Hanko, Rudolf,Hammond, Michael D.,Fruchtmann, Romanis,Pfitzner, Joerg,Place, Graham A.
, p. 1163 - 1170 (2007/10/02)
The synthesis of novel 1-thio-substituted butadienes, designed as mechanism-based 5-lipoxygenase inhibitors, is described.The structure of these compounds closely resembles a proposed high-energy intermediate during the lipoxygenation of arachidonic acid.They demonstrate 5-lipoxygenase inhibition in vitro and in vivo.The most potent compound is 15a with an IC50 of μM in vitro.LTC4 release was inhibited by 80percent after intraperitoneal administration of 15c at a dose of 2 mg/kg.
FOUR NEW C15 ACETYLENIC POLYENES OF BIOGENETIC SIGNIFICANCE FROM THE RED ALGA LAURENCIA OKAMURAI: STRUCTURES AND SYNTHESIS
Kigoshi, Hideo,Shizuri, Yoshikazu,Niwa, Haruki,Yamada, Kiyoyuki
, p. 3781 - 3788 (2007/10/02)
From the red alga Laurencia okamurai four new C15 acetylenic polyenes, laurencenyne 6, neolaurencenyne 8, and trans-neolaurencenyne 9 have been isolated and their structures were elucidated by chemical and spectral means.Synthesis of these four compounds has been made to confirm their structural and stereochemical assigments.Biogenesis of laurencenyne 6 and trans-laurencenyne 8 was discussed.
Inhibitors of SRS-synthesis
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, (2008/06/13)
Methyl derivatives of arachidonic acid and intermediates thereto have been synthesized. These derivatives are inhibitors of SRS-A synthesis and are useful for treating and preventing allergic reactions.
