82407-98-5Relevant academic research and scientific papers
Palladium(II)-Catalyzed C(sp 3)-H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones
Ho, Danny K.H.,Calleja, Jonas,Gaunt, Matthew J.
supporting information, p. 454 - 458 (2019/02/26)
A method for the formal β-functionalization of aliphatic ketones via a palladium-catalyzed sp 3 C-H activation pathway is reported. An N,O-ketal directs an aliphatic C-H carbonylation to form γ-lactams which upon hydrolysis generate γ-keto carb
Synthesis of dioxolanes and oxazolidines by silica gel catalysis
Rohand, Taoufik,Savary, Jér?me,Markó, István E.
, p. 1429 - 1436 (2018/06/25)
Abstract: Ethylene glycol condensed with carbonyl compounds in the presence of silica gel or alumina, without solvent and under pressure, affords 1,3-dioxolanes. 2-Amino-2-methylpropanol also condensed with carbonyl compounds in the presence of silica gel or an acid-activated clay, without solvent and under pressure, produces oxazolidines. To explain these results, we propose that the glycol and the aminopropanol react with Br?nsted (H+) and Lewis acid sites (Si and Al) located on the surface of the catalysts, leading to the products via various ionic intermediates.
