82408-06-8

Upstream product

• 141104-11-2 N-pyridinium chloride 
• 39222-69-0 3-[(2-aminophenyl)amino]-5,5-dimethylcyclohex-2-en-1-one 
• 89-98-5 2-chloro-benzaldehyde 
• 126-81-8 dimedone 
• 95-54-5 1,2-diamino-benzene 

Relevant academic research and scientific papers

A nickel nanoparticle engineered CoFe2O4@GO-Kryptofix 22 composite: A green and retrievable catalytic system for the synthesis of 1,4-benzodiazepines in water

A composite of Ni nanoparticles incorporated in Kryptofix 22 conjugated magnetic nano-graphene oxide, CoFe2O4@GO-K 22·Ni, was synthesized via the grafting of Kryptofix 22 moieties on the magnetic nano-graphene oxide surface, followed by reaction of the nanocomposite with nickel nitrate. The Kryptofix 22 host material unit cavities can stabilize the Ni nanoparticles effectively and prevent their aggregation and separation from the surface. Characterization of the catalysts by FT-IR, FE-SEM, TGA, ICP, EDX, XRD, VSM and BET aided understanding the catalyst structure and morphology. This catalyst was efficiently applied for the synthesis of 1,4-benzodiazepine derivatives. The main advantages of the method are mild reaction conditions, inexpensive catalyst, it is environmentally benign, has high to excellent yields and shorter reaction times. This organometallic catalyst can be easily separated from a reaction mixture and was successfully examined for six runs with a slight loss of catalytic activity.

Propylphosphonic anhydride (T3P)-mediated three-component synthesis of hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives

[Figure not available: see fulltext.] In this work, the novel approach via propylphosphonic anhydride (T3P)-promoted synthesis of 1,5-benzodiazepines from o-phenylene-diamine, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic aldehydes

Synthesis and characterization of CoFe2O4@SiO2@NH-NH2-PCuW as an acidic nano catalyst for the synthesis of 1,4-benzodiazepines and a powerful dye remover

A novel magnetic heterogeneous nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW was synthesized and characterized. This powerful catalyst possesses Br?nsted and Lewis acid properties. The presence of Cu enhances the acidity of this catalyst because of the increase in the electron deficiency of polyoxometalate. It was successfully applied for the easy and efficient one-pot synthesis of 1,4-benzodiazepine derivatives directly from dimedone, o-phenylenediamine, and an aromatic aldehyde under a solvent-free condition at 80 °C. High yields in short reaction times, easy work-up, and environmental friendliness are some of the advantages of this protocol. Also, this nanocatalyst could conveniently be recovered by a magnetic field and reused several times without a significant loss of catalytic efficiency. The synthesized nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW also proved to be an excellent adsorbent for dye removal. These properties are related to the high surface area because of the nanostructure and high acidity due to the presence of Cu in polyoxometalate. Moreover, magnetic properties help better recovering of this adsorbent for dye removed from wastewater.

Organocatalytic Green Approach Towards the Fabrication of Fused Benzo N,N-containing Heterocycles Facilitated by Ultrasonic Irradiation

The development of a metal-free protocol for transformations in organic synthesis offers a significant potential environmental benefit. This article reports the exploration of meglumine, a nontoxic and biodegradable amino sugar, as an organocatalyst for the synthesis of biologically active 1H-dibenzo[b,e][1,4]diazepin-1-ones, highly regioselective benzimidazole derivatives and derivatives of quinoxalines. Operational simplicity, mild reaction conditions, shorter reaction times, and use of green solvents are the highlights of this protocol. The advantage of ultrasonic irradiation has been significantly explored for the synthesis of the aforesaid compounds. Furthermore, the multifaceted use of o-phenylenediamine has also been accentuated in the study.

Silica-supported NiO nanocomposites prepared: Via a sol-gel technique and their excellent catalytic performance for one-pot multicomponent synthesis of benzodiazepine derivatives under microwave irradiation

Heterogeneous and versatile NiO-SiO2 NCs were synthesized by a sol-gel technique and used as a catalyst for the one-pot multicomponent synthesis of benzodiazepine derivatives (4a-u) from a mixture of o-phenylenediamine, aromatic aldehydes and d

An efficient, environmentally benign, and solvent-free protocol for the synthesis of 4-substituted 1,5-benzodiazepines catalyzed by reusable sulfated polyborate

An efficient and environmentally benign method has been developed for the one-pot solvent-free synthesis of 4-substituted-1,5-benzodiazepines via three-component reaction of o-phenylenediamine, dimedone with a variety of aldehydes catalyzed by sulfated po

Practical carbocatalysis by graphene oxide nanosheets in aqueous medium towards the synthesis of diversified dibenzo[1,4]diazepine scaffolds

GO nanosheets are found to be an efficient recyclable carbocatalyst for the construction of diversified dibenzo[1,4]diazepine nuclei starting from o-phenylenediamine, various aldehyde/ketone and 1,3-diketo compounds in aqueous medium. This new metal free

Facile three-component preparation of benzodiazepine derivatives catalyzed by zinc sulfide nanoparticles via grinding method

Abstract: In this research, ZnS nanoparticles were prepared and applied as heterogeneous reusable catalyst for synthesis of 1,5-benzodiazepines under grinding conditions at 70?°C. The multi-component reactions of aldehydes, dimedone and o-phenylenediamine

Method for catalytic preparation of 1,5-benzodiazepine derivative

The invention discloses a method for catalytic preparation of a 1,5-benzodiazepine derivative and belongs to the technical field of ionic liquid catalysis. During reaction for preparation, the molar ratio of o-phenylenediamine to 5,5-dimethyl-1,3-cyclohexandion to aromatic aldehyde is 1: 1: 1; the molar weight of an acidic ionic liquid catalyst is 10-15% of that of aromatic aldehyde; the volume dose of a reaction solvent (85% ethanol water solution) by milliliter is 5-8 times of the matter amount of aromatic aldehyde by millimole; the reflow reaction time is 10-20 min; cooling to the room temperature is performed after finish of the reaction; suction filtration is conducted; the residue is vacuum-dried to obtain the 1,5-benzodiazepine derivative. Compared with preparation methods adopting other acidic ionic liquid catalysts, the method provided by the invention has the characteristics that the consumption of the catalyst is low, the raw material utilization ratio is high and the operation in the whole preparation process is simple and convenient, and industrial large-scale application is facilitated.

ZnS nanoparticles as an efficient recyclable heterogeneous catalyst for one-pot synthesis of 4-substituted-1,5-benzodiazepines

An efficient and novel method was developed for the synthesis of 4-substituted-1,5-benzodiazepine derivatives via a one-pot three-component catalytic reaction. The o-phenylenediamine and dimedone were reacted with aldehyde derivatives in the presence of ZnS nanoparticles as a heterogeneous catalyst under thermal conditions. The reaction was completed with high to excellent product yields and short reaction times. Simplicity of operation, high yields, easy work-up, easily accessible catalyst and purification of products through a crystallization method (non-chromatographic) are the key advantages of this work.