82413-48-7

Upstream product

• 4224-70-8 6-bromohexanoic acid 
• 22809-37-6 6-bromohexanoyl chloride 
• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 
• 1251831-76-1 2-(5-bromo-2-pentenyl)-3-methyl-5,6-dimethoxy-1,4-benzoquinone 

Downstream Products

• 1234208-23-1 2,3-dimethoxy-5-(5-azidopentyl)-6-methyl-1,4-benzoquinone 
• 1309779-62-1 bis-6-(10-mercaptopentyl)-bisubiquinone 
• 1319741-64-4 6-(5-thioacetylpentyl)-ubiquinone 
• 1319741-62-2 2,3,4,5-tetramethoxy-6-(5-bromopentyl)-toluene 
• 1319741-63-3 2,3,4,5-tetramethoxy-6-(5-thioacetylpentyl)-toluene 

Relevant academic research and scientific papers

Reversible redox of NADH and NAD+ at a hybrid lipid bilayer membrane using ubiquinone

Here, we report the reversible interconversion between NADH and NAD + at a low overpotential, which is in part mediated by ubiquinone embedded in a biomimetic membrane to mimic the initial stages of respiration. This system can be used as a platform to examine biologically relevant electroactive molecules embedded in a natural membrane environment and provide new insights into the mechanism of biological redox cycling.

Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins

Quinones are essential components in most cell and organelle bioenergetic processes both for direct electron and/or proton transfer reactions but also as means to regulate various bioenergetic processes by sensing cell redox states. To understand how quin

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.