82420-62-0

Upstream product

• 67-56-1 methanol 
• 27892-88-2 (E)-4-nitrocinnamonitrile 
• 109-77-3 malononitrile 
• 174872-72-1 2-(4-nitrophenyl)-1,1,3-propanetricarbonitrile 

Downstream Products

• 174872-68-5 6-Amino-4-(4-amino-phenyl)-2-methoxy-nicotinonitrile 

Relevant academic research and scientific papers

On the mechanism of formation of pyridines from α,β-unsaturated nitriles and active cyano compounds

The mechanism of formation of pyridines from α,β-unsaturated nitriles and active cyano compounds has been investigated. These processes proceed through a Michael adduct which undergoes a regioselective cyclization to the corresponding heterocyclic compound. The regioselectivity of the heterocyclization processes is justified.

Synthese d'heterocycles. XX (1). Reaction du malononitrile avec quelques cinnamonitriles

Reaction of cinnamonitriles with malononitrile, in methanol-methoxide, yield dihydropyridines, which by aromatisation give pyridines.Pyridine is directly obtained when p-nitrocinnamonitrile is used.