82423-35-6Relevant articles and documents
Method for removing 17-acetoxy group from steroid compound
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Paragraph 0017-0020, (2019/11/20)
The invention discloses a method for removing a 17-acetoxy group from a steroid compound. A 17-acetoxy steroid compound is added to a low boiling solvent such as a halogenated hydrocarbon, an aliphatic hydrocarbon, an aromatic hydrocarbon, tetrahydrofuran or dioxane, an organic alkali is added, and a reaction is performed to form a steroid compound. The method improves the yielding rate of the reaction, and avoids the traditional high-boiling, difficult-to-treat and high-pollution solvents such as DMF and DMSO, so the method is suitable for industrial production.
A preparation method of budesonide
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, (2017/08/25)
The invention discloses a budesonide preparing method. Prednisone I and acetic anhydride II react to produce 17,21-diacetoxy-1,4-pregnane diene-3,11,20-triketone III, the III is degreased in an anhydrous solvent to obtain 21-acetoxyl group-1,4,16-pregnane diene-3,11,20-triketone IV, the IV is oxidized to obtain 16alpha,17alpha-dyhydroxy-21-acetoxyl-1,4-pregnane diene-3,11,20-triketone V, the V and n-butyl aldehyde VI are condensed to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-21-acetoxyl group-1,4-pregnane diene-3,11,20-triketone VII, the VII is reduced to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-11beta-hydroxyl-21-acetoxyl group-1,4-pregnane diene-3,20-diketone VIII, the VIII is subjected to base catalysis to obtain budesonide IX. The budesonide preparing method is suitable for industrial production.
