6677-19-6

Basic information

• Product Name: Prednisone 17, 21-Diacetate
• Synonyms: Prednisone 17, 21-Diacetate;17,21-Bis(acetyloxy)-pregna-1,4-diene-3,11,20-trione;17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione Diacetate
• CAS NO: 6677-19-6
• Molecular Formula: C₂₅H₃₀O₇
• Molecular Weight: 442.5015
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 6677-19-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform
• CAS DataBase Reference: Prednisone 17, 21-Diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Prednisone 17, 21-Diacetate(6677-19-6)
• EPA Substance Registry System: Prednisone 17, 21-Diacetate(6677-19-6)

Safety Data

• Hazardous Substances Data: 6677-19-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Adrenocortical steroid. Antiinflammatory.

Upstream product

• 53-03-2 Prednison 
• 108-24-7 acetic anhydride 
• 125-10-0 prednisone acetate 
• 64-19-7 acetic acid 

Downstream Products

• 83291-83-2 Acetic acid 2-((4aR,4bS,5S,6aS,6bR,9aS,10aS,10bS)-8-benzyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahydro-7-oxa-8-aza-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester 
• 3044-42-6 21-acetoxy-11β-hydroxyl-1,4,16-pregnatriene-3,20-dione 
• 82423-35-6 21-acetoxypregna-1,4,16-triene-3,11,20-trione 

Relevant articles and documents

A preparation method of budesonide

The invention discloses a budesonide preparing method. Prednisone I and acetic anhydride II react to produce 17,21-diacetoxy-1,4-pregnane diene-3,11,20-triketone III, the III is degreased in an anhydrous solvent to obtain 21-acetoxyl group-1,4,16-pregnane diene-3,11,20-triketone IV, the IV is oxidized to obtain 16alpha,17alpha-dyhydroxy-21-acetoxyl-1,4-pregnane diene-3,11,20-triketone V, the V and n-butyl aldehyde VI are condensed to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-21-acetoxyl group-1,4-pregnane diene-3,11,20-triketone VII, the VII is reduced to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-11beta-hydroxyl-21-acetoxyl group-1,4-pregnane diene-3,20-diketone VIII, the VIII is subjected to base catalysis to obtain budesonide IX. The budesonide preparing method is suitable for industrial production.

ISOXAZOLIDINE DERIVATIVES

The present invention relates to novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, methods of preparing such compounds, pharmaceutical compositions comprising them, combinations and therapeutic uses thereof. More particularly, the invention relates to glucocorticosteroids that are derivatives of isoxazolidine.

ISOXAZOLIDINE DERIVATIVES

Novel glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds.