82430-61-3

Upstream product

• 82414-23-1 3-(2,4,6-Trimethyl-phenyl)-3a,8b-dihydro-isoxazolo[4,5-b]indole-4-carboxylic acid ethyl ester 
• 13307-67-0 ethyl 1H-indole-1-carboxylate 
• 1496-76-0 N-benzoylindole 
• 576-15-8 N-acetylindole 
• 91477-00-8 3-(2,4,6-Trimethyl-phenyl)-3a,8b-dihydro-isoxazolo[4,5-b]indole-4-carboxylic acid methyl ester 
• 91476-92-5 1-[3-(2,4,6-Trimethyl-phenyl)-3a,8b-dihydro-isoxazolo[4,5-b]indol-4-yl]-ethanone 
• 58881-45-1 Indole-2-carbonyl chloride 
• 88-05-1 2,4,6-trimethylaniline 

Relevant academic research and scientific papers

HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE

Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

SELECTIVITY IN CYCLOADDITIONS-IX CYCLOADDITIONS OF NITRILE OXIDES TO INDOLES. REACTIVITY AND REGIOCHEMISTRY

Cycloadditions of benzonitrile oxide and mesitonitrile oxide to N-methylindole and indole yield the acid sensitive cycloadducts 1 a-d with high regioselectivity.With N-carbethoxyindole the stable cycloadducts 1 e,f and minor amounts of the regioisomeric 2 e,f are isolated.The electron withdrawing substituent reduces both the regioselectivity and the reactivity of the cycloadditions.Frontier orbital considerations, based on MINDO/3 calculations, allow elucidation of the observed changes in reactivity and regiochemistry.