82434-57-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 58-96-8 uridine 

Downstream Products

• 96026-68-5 5'-O-(4,4'-dimethoxytrityl)-3'-O-(levulinyl)uridine 
• 1332729-08-4 diisopropyl [2-O-benzoyl-1-(uracil-1-yl)-5-O-dimethoxytrityl-β-D-ribofuranos-3-O-yl]methylphosphonate 
• 1332729-15-3 4-methoxy-1-oxido-2-pyridylmethyl-[2-O-benzoyl-1-(uracil-1-yl)-5-O-dimethoxytrityl-β-D-ribofuranos-3-O-yl]methylphosphonate 

Relevant academic research and scientific papers

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

New catalists and procedures for the dimethoxytritylation and selective silylation of ribonucleosides

Procedures have been developed for the selective formation of (a) 2',5'-silylated ribonucleosides and (b) 3',5'-silylated ribonucleosides.These procedures also permit the selective silylation at either the 2'- or 3'-position of dimethoxytritylated ribonuc