96026-68-5

Upstream product

• 58-96-8 uridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 123-76-2 levulinic acid 
• 81246-79-9 5'-dimethoxytrityluridine 
• 40608-06-8 levulinic anhydride 
• 82434-57-9 1-(2,5-O-bis-dimethoxytrityl-β-D-ribofuranosyl)uracil 

Relevant academic research and scientific papers

Solid-phase synthesis and on-column deprotection of RNA from 2′- (and 3′-) O-Levulinated (Lv) ribonucleoside monomers

(Chemical Equation Presented) The solid-phase synthesis of oligoribonucleotides derived from ribonucleosides esterified at the 2′ (or 3′-) position with the levulinyl (Lv) group is described. The oligomers can be released from the solid support as 2′-O-Lv

Hydrolytic stability of a phosphate-branched oligonucleotide incorporating a ribonucleoside 3′-phosphotriester unit

A phosphate-branched oligonucleotide has been prepared by using an appropriately protected trinucleoside phosphotriester building block in conventional solid-phase synthesis. Hydrolysis of the branched oligonucleotide has been followed over a wide pH range. Comparison of the present results with those previously obtained for simpler analogues indicates that a trinucleoside 3′,3′,5′-monophosphate, when embedded in an oligonucleotide structure, is stabilized toward hydroxide-ion catalyzed cleavage by more than one order of magnitude, lending some support to the feasibility of existence of phosphate-branched RNA X in biological systems. Copyright Taylor & Francis Group, LLC.