824398-22-3

Upstream product

• 824397-90-2 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 10272-07-8 3.5-dimethoxyaniline 
• 32249-35-7 methyl 3-cyclopropyl-3-oxopropanoate 
• 824397-58-2 2-cyano-3-(3,5-dimethoxyphenylamino)-3-methylsulfanylacrylonitrile 
• 947155-02-4 5-amino-3-(3,5-dimethoxyphenylamino)pyrazole-1H-4-carbonitrile 

Downstream Products

• 824399-05-5 7-(2-amino-2-methylpropylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-68-4 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-[(S)-2-hydroxy-1-(1H-indol-3-ylmethyl)ethylamino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-65-1 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((S)-2-hydroxymethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-67-3 7-((R)-1-benzyl-2-hydroxyethylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-66-2 7-((S)-1-benzyl-2-hydroxyethylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 824398-80-3 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((R)-1-hydroxymethyl-2-methylpropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-64-0 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((R)-2-hydroxymethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1018686-69-5 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((S)-1-hydroxymethyl-2-pyridin-3-ylethylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 

Relevant academic research and scientific papers

Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade

To improve the in vitro potency of the c-Src inhibitor 1a and to address its hERG liability, a structure-activity study was carried out, focusing on two regions of the lead compound. The blockade of the delayed cardiac current rectifier K+ (IKr) channel was overcome by replacing the ethylenediamino group with an amino alcohol group at the 7-position. In addition, modifying the substituents at the 5-position and the side chain groups on the amino alcohols at the 7-position enhanced the intracellular c-Src inhibitory activity and increased central nervous system (CNS) penetration. In the present study, 6l exhibited significant in vivo efficacy in a middle cerebral artery (MCA) occlusion model in rats.

Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke

We synthesized a series of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives and evaluated their ability to inhibit c-Src kinase; 7-(2-amino-2-methylpropylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino) pyrazolo-[1,5-a]pyrimidine-3-carboxamide 7o and