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Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-cyclopropyl-2-[(3,5-dimethoxyphenyl)amino]-7-[[(1R)-1-(hydroxymethyl )-2-methylpropyl]amino]- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

824398-80-3

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824398-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 824398-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,4,3,9 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 824398-80:
(8*8)+(7*2)+(6*4)+(5*3)+(4*9)+(3*8)+(2*8)+(1*0)=193
193 % 10 = 3
So 824398-80-3 is a valid CAS Registry Number.

824398-80-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((R)-1-hydroxymethyl-2-methylpropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:824398-80-3 SDS

824398-80-3Downstream Products

824398-80-3Relevant academic research and scientific papers

Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade

Mukaiyama, Harunobu,Nishimura, Toshihiro,Kobayashi, Satoko,Komatsu, Yoshimitsu,Kikuchi, Shinji,Ozawa, Tomonaga,Kamada, Noboru,Ohnota, Hideki

, p. 909 - 921 (2008/09/17)

To improve the in vitro potency of the c-Src inhibitor 1a and to address its hERG liability, a structure-activity study was carried out, focusing on two regions of the lead compound. The blockade of the delayed cardiac current rectifier K+ (IKr) channel was overcome by replacing the ethylenediamino group with an amino alcohol group at the 7-position. In addition, modifying the substituents at the 5-position and the side chain groups on the amino alcohols at the 7-position enhanced the intracellular c-Src inhibitory activity and increased central nervous system (CNS) penetration. In the present study, 6l exhibited significant in vivo efficacy in a middle cerebral artery (MCA) occlusion model in rats.

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