824402-83-7Relevant academic research and scientific papers
Synthesis of laminarin fragments and evaluation of a β-(1,3) glucan hexasaccaride-CRM197 conjugate as vaccine candidate against Candida albicans
Adamo, Roberto,Tontini, Marta,Brogioni, Giulia,Romano, Maria Rosaria,Costantini, Gabriele,Danieli, Elisa,Proietti, Daniela,Berti, Francesco,Costantino, Paolo
experimental part, p. 249 - 280 (2012/04/17)
Laminarin-CRM197 glycoconjugates were previously demonstrated to be immunogenic and confer protection against Candida albicans in mice. Laminarin consists of β-(1,3) glucan repeating units, with sporadic β-(1,6) branches. A set of short glucans was used to study the effect of the β-(1,6) branch on the antigenicity of linear β-(1,3) glucans. A linear β-(1,3) glucan hexasaccharide was selected as the best fragment able to inhibit the binding between laminarin and antilaminarin antibodies. The hexamer was then conjugated to CRM197 and induced, in mice, significant titers of specific antilaminarin antibodies comparable with those raised by the Lam-CRM197 conjugate. Copyright Taylor & Francis Group, LLC.
Synthesis of (R)-2,3-epoxypropyl(1→3)-β-D-pentaglucoside
Huang, Gang-Liang,Mei, Xin-Ya,Liu, Man-Xi
, p. 603 - 608 (2007/10/03)
The title pentasaccharide was synthesized via a 2 + 3 strategy. The disaccharide donor, 3-O-acetyl-2-O-benzoyl-4,6-O-benzylidene-β-d- glucopyranosyl-(1→3)-2-O-benzoyl-4,6-O-benzylidene-α-d- glucopyranosyl trichloroacetimidate (8), was obtained by selectiv
Synthesis, (1→3)-β-d-glucanase-binding ability and phytoalexin-elicitor activity of (R)-2,3-epoxypropyl (1→3)-β-d- pentaglucoside
Huang, Gang-Liang,Mei, Xin-Ya,Liu, Man-Xi,Liu, Tian-Cai
, p. 6027 - 6029 (2007/10/03)
The (1→3)-β-d-pentaglucoside was synthesized as its (R)-2,3-epoxypropyl glycoside via 2 + 3 strategy. The disaccharide donor 8 was obtained by 3-selective coupling of 2 with 4, followed by deallylation, and trichloroacetimidation. Meanwhile, the trisaccha
