824403-28-3Relevant academic research and scientific papers
Development of CXCR3 antagonists. Part 4: Discovery of 2-amino-(4-tropinyl)quinolines
Knight, Roland L.,Allen, Daniel R.,Birch, Helen L.,Chapman, Gayle A.,Galvin, Frances C.,Jopling, Louise A.,Lock, Christopher J.,Meissner, Johannes W.G.,Owen, David A.,Raphy, Gilles,Watson, Robert J.,Williams, Sophie C.
, p. 629 - 633 (2008)
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physicochem
BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF CXCR3 FUNCTION
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Page 41, (2010/02/10)
A class of 1-substituted 4-(benzothiazol-2-ylamino) piperidine derivatives and related heterocyclic compounds, being potent and selective modulators of the interaction between CXCR3 and its chemokine ligands, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immunoregulatory disorders.
