147539-41-1

Basic information

• Product Name: 1-Boc-4-Methylaminopiperidine
• Synonyms: N-BOC-4-METHYLAMINOPIERIDINE;N-BOC-4-METHYLAMINOPIPERIDINE;N-BOC-4-N-METHYLAMINO PIPERIDINE;tert-butyl 4-(methylamino)piperidine-1-carboxylate;BUTTPARK 90\06-11;1-N-BOC-4-(METHYLAMINO)PIPERIDINE;1-BOC-4-METHYLAMINOPIPERIDINE;4-N-METHYLAMINO-1-BOC-PIPERIDINE
• CAS NO: 147539-41-1
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Product Categories: pharmacetical;Piperidine
• Mol File: 147539-41-1.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 289.003 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.005 g/mL at 25 °C
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: n20/D1.468
• Storage Temp.: Room temperature.
• PKA: 10.19±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-4-Methylaminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-Methylaminopiperidine(147539-41-1)
• EPA Substance Registry System: 1-Boc-4-Methylaminopiperidine(147539-41-1)

Safety Data

• Hazard Codes: Xi,N,T
• Statements: 36/37/38-50-25
• Safety Statements: 26-61-45-36/37/39
• RIDADR: 2810
• WGK Germany: 3
• F: 10-34
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 147539-41-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Different sources of media describe the Uses of 147539-41-1 differently. You can refer to the following data:
1. 1-Boc-4-(methylamino)piperidine is used as an organic chemical synthesis intermediate.
2. 1-Boc-4-methylaminopiperidine is a derivatieve of 3-Methylaminopiperidine Dihydrochloride, which is a a key intermediate for the antibacterial agent balofloxacin.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-9(12-4)6-8-13/h9,12H,5-8H2,1-4H3

Upstream product

• 546-68-9 titanium(IV) isopropylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 191212-86-9 tert-butyl 4-(N-benzyl-N-methylamino)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7144-05-0 4-Aminomethylpiperidine 
• 56553-60-7 sodium tris(acetoxy)borohydride 
• 107-06-2 1,2-dichloro-ethane 
• 847039-05-8 4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 301220-70-2 4-(N-(2-phenylethyl)amino)-1-(tert-butoxycarbonyl)piperidine 

Downstream Products

• 278793-51-4 C₃₃H₃₅Cl₃N₆O₄S 
• 197727-57-4 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester 
• 301232-33-7 4-(N-(N-(4-nitrobenzyl)carbamoyl)-N-methylamino)-piperidine trifluoroacetate 
• 847039-05-8 4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 1062461-68-0 C₂₄H₃₅F₂N₃O₃ 
• 494861-60-8 C₂₃H₃₄F₂N₄O₃ 
• 494861-73-3 C₂₄H₃₇N₃O₃ 
• 494861-75-5 C₂₄H₃₇N₃O₃ 
• 1383342-71-9 1,1-dimethylethyl 4-[methyl(phenylcarbonyl)amino]-1-piperidinecarboxylate 
• 925920-88-3 tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate 
• 618429-73-5 4-[(2S-benzyloxycarbonylamino-3,3-dimethylbutyryl)methylamino]piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of N,N-dialkyl-1-(2-alkylthiopyrimidin-4-yl)piperidin- 4-amines as potential heat shock protein inhibitors

A new efficient method for synthesizing promising heat shock protein inhibitors, N,N-dialkyl- 1-(2-alkylthiopyrimidin-4-yl)piperidin-4-amines, by the reaction of 2-alkyl-4-chlorothiouracils with 4-(N-alkyl-N-methylamino)piperidines was developed. 2-Alkyl-4-chlorothiouracils were synthesized by alkylation of 2-thiouracil with alkyl iodides and subsequent treatment of the intermediates with POCl3. 4-(N-Alkyl-N-methylamino)piperidines were prepared by reductive amination of 1-(tert-butoxycarbonyl)-4-piperidinone with methylamine followed by treatment of the intermediate with the appropriate aldehydes.

Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors

A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50 = 0.48 μM) than LY2940680 (IC50 = 0.79 μM).

SMO (smoothened) inhibitor containing benzoylpiperidine structure and preparation and application methods thereof

The invention discloses a benzoylpiperidine derivative and preparation and application methods thereof. The benzoylpiperidine derivative is a compound containing N-methyl-N-(1-(2-aminobenzoyl)piperidine-4-yl)amide structure shown as the formula I. The invention also discloses a preparation method of the benzoylpiperidine derivative. The invention also discloses application of the benzoylpiperidinederivative to preparing SMO protein inhibitors as well as application of drug combinations containing the benzoylpiperidine derivative to preparing anti-tumor drugs.