824414-06-4 Usage
Uses
Used in Pharmaceutical Drug Synthesis:
2-(PIPERAZIN-1-YL)PROPIONIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of new medications targeting neurological disorders and psychiatric illnesses.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(PIPERAZIN-1-YL)PROPIONIC ACID ETHYL ESTER is utilized as a research chemical to study biological processes and understand the mechanisms of action for potential therapeutic agents.
Used in Drug Development:
2-(PIPERAZIN-1-YL)PROPIONIC ACID ETHYL ESTER is employed as a building block in drug development for creating novel compounds with therapeutic properties, enhancing the discovery of new treatments for various medical conditions.
Used in the Study of Biological Processes:
2-(PIPERAZIN-1-YL)PROPIONIC ACID ETHYL ESTER is also used in the study of biological processes to explore its interactions with biological systems and understand its potential effects on different physiological pathways, which can contribute to the advancement of medical knowledge and treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 824414-06-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,4,4,1 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 824414-06:
(8*8)+(7*2)+(6*4)+(5*4)+(4*1)+(3*4)+(2*0)+(1*6)=144
144 % 10 = 4
So 824414-06-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H18N2O2/c1-3-13-9(12)8(2)11-6-4-10-5-7-11/h8,10H,3-7H2,1-2H3
824414-06-4Relevant academic research and scientific papers
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists
Chiba, Jun,Takayama, Gensuke,Takashi, Tohru,Yokoyama, Mika,Nakayama, Atsushi,Baldwin, John J.,McDonald, Edward,Moriarty, Kevin J.,Sarko, Christopher R.,Saionz, Kurt W.,Swanson, Robert,Hussain, Zahid,Wong, Angela,MacHinaga, Nobuo
, p. 2725 - 2746 (2007/10/03)
A series of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives were synthesized and evaluated for their activity as VLA-4 antagonists. Of 22 compounds synthesized, 19 compounds showed potent activity with low nanomolar IC50 values. In addition, the representative compounds 11o and 11p with a hydroxy group in the pyrrolidine ring showed moderate plasma clearance in rats (11o, 30 ml/min/kg and 11p, 21 ml/min/kg) and in dogs (11o, 12 ml/min/kg and 11p, 9 ml/min/kg).
