82475-67-0

Basic information

• Product Name: tert-butyl(dimethyl)silyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate
• CAS NO: 82475-67-0
• Molecular Formula: C₂₀H₃₃Cl₂NO₂Si
• Molecular Weight: 418.473
• Mol File: 82475-67-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 467.8°C at 760 mmHg
• Flash Point: 236.7°C
• Density: 1.08g/cm³
• Vapor Pressure: 6.3E-09mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: tert-butyl(dimethyl)silyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl(dimethyl)silyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate(82475-67-0)
• EPA Substance Registry System: tert-butyl(dimethyl)silyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate(82475-67-0)

Safety Data

• Hazardous Substances Data: 82475-67-0(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 305-03-3 chlorambucil 

Relevant articles and documents

Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs

N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.