824940-77-4

Upstream product

• 108-98-5 thiophenol 
• 510730-08-2 (1R,5R)-5-methyl-2-oxo-1-(2,4,6-trimethylphenylsulfonyl)bicyclo[3.1.0]hexane 

Downstream Products

• 70117-00-9 (+)-allocyathin B₂ 
• 824940-68-3 dithiocarbonic acid O-[2-[(1S,2S,6S)-2-(tert-butyl-dimethylsilanyloxy)-6-(4-methoxybenzyloxy)-1-methylcyclohexyloxy]-1-[(7S)-7-methyl-1,4-dioxa-spiro[4.4]non-7-yl]-ethyl] ester S-methyl ester 
• 824940-67-2 2-[(1S,2S,6S)-2-(tert-butyl-dimethylsilanyloxy)-6-(4-methoxybenzyloxy)-1-methylcyclohexyloxy]-1-[(7S)-7-methyl-1,4-dioxa-spiro[4.4]non-7-yl]-ethanol 
• 824940-69-4 (+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane 
• 824940-70-7 (+)-(3aS,5aS,6S,9aR,9bR)-6-(4-methoxybenzyloxy)-decahydro-9a-hydroxy-3a,5a-dimethyl-2H-cyclopenta[a]naphthalen-1(9bH)-one 
• 824940-81-0 (+)-(S)-3-(2-((1R,2S,6S)-2-(4-methoxybenzyloxy)-6-hydroxy-1-methylcyclohexyl)ethyl)-3-methylcyclopentanone 
• 824940-61-6 (+)-(2S,3S)-4-(4-methoxybenzyloxy)-2-methyl-2-(2-((S)-1-methyl-3-oxocyclopentyl)ethyl)cyclohexanone 
• 824940-72-9 (+)-(3aS,5aR,6S)-6-(4-methoxybenzyloxy)-2,3,3a,4,5,5a,6,7,8,9-decahydro-3a,5a-dimethyl-cyclopenta[a]naphthalen-1-one 
• 824940-71-8 (+)-(3aS,5aR,6S,9bR)-6-(4-methoxybenzyloxy)-3,3a,4,5,5a,6,7,8-octahydro-3a,5a-dimethyl-2H-cyclopenta[a]naphthalen-1(9bH)-one 
• 824940-79-6 (S)-7-benzenesilfinylmethyl-7-methyl-1,4-dioxa-spiro[4.4]nonane 
• 824940-78-5 (S)-7-methyl-7-phenylsulfanylmethyl-1,4-dioxa-spiro[4.4]nonane 
• 824940-64-9 (S)-3-methyl-3-((phenylthio)methyl)cyclopentanone 

Relevant academic research and scientific papers

Synthetic studies on cyathins: Enantioselective total synthesis of (+)-allocyathin B2

(Chemical Equation Presented) The enantioselective total synthesis of (+)-allocyathin B2 has been achieved. Our approach features a convergent enantioselective construction of the 5-6-7 tricyclic core system using the originally developed chira

Enantioselective preparation of C-ring fragment of cotylenin A via catalytic asymmetric intramolecular cyclopropanation of α-diazo β-keto ester

A synthetic pathway to the C-ring fragment of cotylenin A which emerged from our retrosynthetic analysis of cotylenin A is described. The catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of the α-diazo-β-keto ester bearing 2,4,6-trimethylphenyl group as the ester part has been found to afford the crystalline product with high ee, which allowed to establish the approach to the C-ring fragment which required ten-pot operations. The developed approach would be beneficial to a large scale synthesis of the C-ring fragment for the total synthesis of cotylenin A.